摘要
重症肌无力为难治性疾病,属中医"痿证"范畴,调理脾胃是中医临床常用治法。肌肉运动无力为其最突出表现,实质上是骨骼肌的收缩与舒张失常。骨骼肌的收缩和舒张是一种耗能运动,需要线粒体参与供能。研究发现,重症肌无力患者肌肉组织存在线粒体形态结构异常[1],而重症肌无力模型大鼠也存在骨骼肌线粒体结构与功能的改变[2]。线粒体融合分裂不仅在维持线粒体自身的结构功能方面扮演着重要角色,还与神经、骨骼肌病变等密切相关,故有必要从线粒体融合分裂角度,进一步探讨脾胃失调与重症肌无力的相关性。
As refractory disease, Myasthenia gravis belongs to Chinese medicine flaccidity. Regul^ating spleen and stomach method is commonly used in clinical treatment of traditional Chinese medicine. The muscle weakness is the most prominent performance which in essence is the contractile and diastolic dysfunction of skeletal muscle. As energy con-sumption sport, the contraction and dilatation of skeletal muscle needs energy supplied by mitochondria. The research shows that there is abnormal mitochondria morphology in muscle tissue of myasthenia gravis patients and also there is mitochondrial structure and function change in skeletal muscle of myasthenia gravis rats. Mitochondrial fusion and fission not only plays an important role in maintainance of structure and function of mitochondria, but also is closely related to nervous and skeletal muscle diseases. Therefore,it is necessary to further explore the relationship between spleen and stomach disorders and myasthenia gravis based on mitoehondrial fusion and fission.
出处
《中华中医药学刊》
CAS
北大核心
2017年第1期127-129,共3页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金项目(81473568)
广东省中医内科学"特色重点学科建设项目"项目(粤财教[2010]356)
广州中医药大学科研创新基金项目(10CX084)
广州中医药大学"薪火计划"(XH20160106)
关键词
重症肌无力
线粒体
融合分裂
myasthenia gravis
mitoehondria
fusion and fission
