摘要
目的:研究黄花远志根和叶提取物对四氯化碳(CCl4)所致急性肝损伤小鼠的保护作用。方法:采用CCl4诱导化学性急性肝损伤模型,测定小鼠肝脏指数、血清丙氨酸氨基转移酶(ALT)和天门冬氨酸氨基转移酶(AST),观察小鼠肝脏病理学变化。结果:黄花远志根(4 g、2 g生药/kg)和叶(4 g、2 g生药/kg)提取物能显著降低CCl4致小鼠急性肝损伤ALT和AST的升高,明显改善CCl4对肝组织的病理损伤。结论:黄花远志根和叶对CCl4致小鼠急性肝损伤具有保护作用。
Objective：To study the protective effects of extraction of roots and leaves from Polygala arillta against CCl4-induced liver injury in mice. Methods：The models of acute liver injury were induced by CCl4 in mice. The liver index,serum activities of alanine aminotransferase（ALT） and aspartate aminotransferase（AST） were determined,respectively. Liver tissue sections were examined under a light microscope. Results：In the model of acute liver injury induced by CCl4 in mice,roots（4 g/g and 2 g/kg）and leaves（4 g/kg and 2 g/kg） from Polygala arillta markedly decreased the elevated serum levels of ALT and AST. The extraction of roots and leaves from Polygala arillta effectively improved the tissue lesion of liver. Conclusion：Polygala arillta has a significantly hepatoprotective effect on CCl4-induced acute liver injury in mice.
出处
《天津药学》
2016年第6期15-17,共3页
Tianjin Pharmacy
基金
福建省中青年教师教育科研项目(No.JA14438)
