摘要
目的:探讨膝关节腔内注射联合中频治疗膝骨性关节炎的临床疗效与作用机制。方法:选取120例符合纳入标准的患者,采用随机方式分为三组:A组(n=40)患者均关节腔注射鹿瓜多肽注射液8mg,1次/周,4周/疗程;B组(n=40)在A组治疗方法的基础上+中频治疗(28号处方),qd,20min/次,20次为一个疗程;C组(n=40)患者均采用单纯中频治疗(28号处方),qd,20min/次,20次为一个疗程。观察治疗前后功能评分(VAS、JOA),血清中细胞因子TNF-α、IL-6水平。结果:A组和B组在治疗前后,VAS、JOA评分及TNF-α、IL-6水平差异有统计学意义(P<0.05);但A、B组组间比较,VAS、JOA评分及TNF-α、IL-6水平差异无统计学意义(P>0.05);A、B组与C组比较VAS、JOA评分差异有统计学意义(P<0.05),但TNF-α、IL-6水平方面差异无统计学意义(P>0.05)。结论:膝关节腔内注射联合中频治疗膝骨性关节炎均有抗炎镇痛的功效,临床疗效显著,值得进一步研究。
Objective： To observe clinical efficacy of injection in knee joint plus intermediate frequency on KOA. Methods： 120 cases were divided into 3 groups. 40 cases in the A group took lugua polypeptide injection, 1 time per week, 4 weeks as 1 course; 40 cases in the B group were given intermediate frequency more, 20 minutes per time, 20 time as 1 course. 40 cases in C group received intermediate frequency, 20 minutes per time, 20 time as 1 course. Results： Differences of VAS, JOA, TNF-α and IL-6 between before and after treatment in A and B groups were statistical （P〈0.05）. Differences ofVAS, JOA, TNF-α and IL-6 between A and B groups were not statistical （P〉0.05）; differences ofVAS, JOA among A, B and C groups were statistical （P〈0.05）, and differences of TNF-α, IL-6 were not statistical （P〉0.05）. Conclusion： Injection in knee joint plus intermediate frequency was effective on KOA, and is worthy of further clinical study.
出处
《中医临床研究》
2016年第35期97-99,101,共4页
Clinical Journal Of Chinese Medicine
基金
广东省珠海市科技工贸和信息化局
医学临床研究类课题
项目编号:2014D401990027
