摘要
目的:系列检测50例肝硬化患者血浆凝血因子,分代偿期与失代偿期两组,并分别探索其临床意义。方法:凝血因子抗原测定采取火箭电泳法,凝血因子活性测定采取一期凝血法或发色底物法。结果:除凝血因子Ⅶ活性升高外,其余各凝血因子的抗原性与活性均呈不同程度的降低。其中失代偿期因子Ⅴ与纤维蛋白原的降低显著。结论:因子Ⅴ降低见于肝硬化失代偿期,其降低表明病情恶化与预后不良。
Purpose: The concertration of coagulation factors is detected in 50 patients with cirrhosis (the cases are divided to compensatory phase and decompensatory phase) , which clinical significance is discussed. Methods: Antigens of coagulation factors are detected with rocket electrophoresis method. Activity of coagulation factors is detected with one clotting stage way or chromogenic peptide substrate method. Results: The activity of factor 1/1 was elevated, the antigens and activity of other coagulation factors are decreased and amongst decreasing of FV and fibrinogen only can be seen in decompensatory phase of cirrhosis. GDnclusion: Hemostatic disturbance may be caused by the decrease of antigens and activity of every coagulation factor in patients with cirrhosis. Whereas activity of FW is elevated, it may be the risk factors of venous thrombosis. The decrease of fibrinogen and F V are seen in decompenstaory phase of cirrhosis, which indicated exacerbation of the condition and bad prognosis of cirrhosis patients.
出处
《临床消化病杂志》
2002年第4期171-172,共2页
Chinese Journal of Clinical Gastroenterology
关键词
肝硬化
代偿期
失代偿期
凝血因子
Hepatic cirrhosis Compensatory phase Decompensatory phase Coagulation factor
