摘要
目的:研究胃腺癌局部淋巴结中树突状细胞(DC)对转移和预后的影响。方法:将S-100蛋白作为DC特异性标记物,应用S-P免疫组化方法检测胃腺癌局部淋巴结中DC的数量和分布。结果:转移组淋巴结中DC较非转移组明显减少。在57例转移组中,DC显著者18例,5年生存率55.56％;不明显者39例,5年生存率23.08％。30例非转移组中,DC显著者19例,5年生存率73.68％;不明显者11例,5年生存率36.36％。经x^2检验,在上述两组中,DC显著者的转移和5年生存率与不明显者的差异均有显著性意义(P<0.05)。结论:胃腺癌局部淋巴结中DC程度同转移和预后密切相关。
Purpose: To study the degree of dendritic cells(DC) of regional lymph nodes in relation to metastasis and prognosis of gastric cancer. Methods: S-100 protein as the marker of dendritic cells was stained immunohistochemically in regional lymph nodes of gastric cancer. Results: The degree of DC in metastatic group is much lower than that of non-metastatic group. In 18 of 57 metastatic group, whose DC marked, the five-years survival rate was 55. 56% , while 39 with DC less degree, the five-years survival rate 23. 08% (P< 0. 05). Quite similar data were obtained from 30 non-metastatic group. Significantly higher five-years survival rate was observed in those with marked DC than those with less degree. Conclusion: The degree of DC in regional lymph nodes of gastric cancer was closely correlated with metastasis and prognosis.
出处
《临床消化病杂志》
2002年第4期160-161,共2页
Chinese Journal of Clinical Gastroenterology
关键词
胃肿瘤
树突状细胞
淋巴结转移
预后
Gastric neophasm Dendritric cell Lymph node Metastasis Prognosis
