摘要
非编码RNAs(noncoding RNAs,ncRNAs)包括长链非编码RNAs(long noncoding RNAs,lncRNAs)和小RNAs(microRNAs,miRNAs),与成肌分化、肌纤维类型的调控和骨骼肌疾病关系密切;近期循环ncRNAs成为研究热点,可用作某些疾病的潜在血浆分子标志物,对疾病早期进行筛选。通过研究ncRNAs在骨骼肌发育中的作用及机制将会为骨骼肌疾病的治疗提供潜在靶点。
Noncoding RNAs,including long noncoding RNAs （lncRNAs） and microRNAs （miRNAs）, are close to myogenesis ,regulating of muscle fiber type and muscle diseases. Recently, circulating ncRNAs have become research focus for they could as potential biomarkers for the screening and early diagnosis of some diseases. We are confident that the role of nccoding RNAs during skeletal muscle development will bring potential target for treament of muscle diseases in the future.
作者
陈圣菊
王飞
周越
陈晓萍
CHEN Sheng-Ju WANG Fei ZHOU Yue CHEN Xiao-Ping(Department of Exerise Physiology, Beijing Sport University, Beijing 100084, China National Key Laboratory of Human Factors Engineering, China Astronaut Research and Training Center, Beijing 100094, China)
出处
《生理科学进展》
CAS
CSCD
北大核心
2016年第6期401-406,共6页
Progress in Physiological Sciences
基金
国家自然基金(81501625
31171144
81272177)
航天医学基础与应用国家重点实验室基金(SMFA13A01)
人因工程重点实验室基金(SYFD140051801
SYFD150051802)资助课题
