摘要
目的：观察白细胞介素-2（IL-2）对带状疱疹的治疗效果。方法142例带状疱疹患者以随机数字表法分成治疗组和对照组，109例患者完成临床观察（治疗组48例，对照组61例）。治疗组 IL-250万IU，肌内注射，1次／d，疗程7 d；对照组伐昔洛韦300 mg，口服，2次／d，疗程7 d。两组患者均外用酞丁安软膏。比较两组疗效。结果治疗组和对照组第3天止痛显效及有效率分别为87．5％、68．9％，两组差异有统计学意义（χ2＝4．917，P ＜0．05）；第3天止疱有效及显效率分别为95．8％、82．0％，两组差异有统计学意义（χ2＝5．285，P ＜0．05）；第7天止痛显效及有效率分别为93．8％、78．7％，两组差异有统计学意义（χ2＝4．866，P ＜0．05）。结论 IL-2治疗带状疱疹可以促进止疱，镇痛效果也较为显著。
Objective To evaluate the efficacy of interleukin -2 in the treatment of herpes zoster.Methods 142 patients with herpes zoster were enrolled and randomly divided into the treatment group and control group to receive interleukin -2 injection 500 thousand IU a day or valaciclovir 300mg two times a day respectively for a week. Patients in two groups both received ftibamzone ointment.The evaluations of neuropathic pain were done by using visual analogue scale （VAS）before and during the treatment.The effect was compared between the two groups. Results Significant differences were observed between the treatment group and control group in the effective rate of blister drying（95.8% vs.82.0%,χ2 =4.917,P 〈0.05）and analgesia（87.5% vs.68.9%,χ2 =5.285,P 〈0.05） on the third day,and the effective rate of analgesia on the seventh day （93.8% vs.78.7%,χ2 =4.866,P 〈0.05）. Conclusion Interleukin -2 is effective for the treatment of herpes zoster in shortening the course of blister drying and especially in relieving the pain.
作者
徐建荣
丁以星
夏福林
Xu Jianrong Ding Yixing Xia Fulin(Department of Dermatology, the Center for Disease Control and Prevention of M aanshan, Maanshan, Anhui 243000, Chin)
出处
《中国基层医药》
CAS
2016年第24期3757-3759,共3页
Chinese Journal of Primary Medicine and Pharmacy
