摘要
目的观察芬太尼透皮贴剂对难治性带状疱疹后遗神经痛的疗效及不良反应。方法将带状疱疹后遗神经痛患者30例(常规药物联合神经阻滞治疗1个疗程后VAS>5分)分为曲马多组(T组)、芬太尼组(F组),每组15例。结果两组治疗后VAS评分均降低(P<0.05),F组更为显著(P<0.05)。治疗后两组生活质量评分均明显升高(P<0.05),F组较高(P<0.05)。F组恶心、呕吐发生率较T组低(P>0.05);F组未出现排尿困难,T组发生率为26.67%(P<0.05);T组在治疗后便秘发生率为40%,F组无便秘情况(P<0.05);F组嗜睡的发生率比T组高(P<0.05);两组均未发生呼吸抑制。结论芬太尼透皮贴剂用于难治性带状疱疹后遗神经痛镇痛效果好,不良反应较少。
Objective To evaluate the effects of fentanyl transdermal system on intractable postherpetic neuralgia .Methods 30 patients（after 1 course of conventional drugs with nerve block therapy ,VAS score〉5 points）were randomly divided into tramadol group（group T ） and fentanyl group（group F） ,15 cases in each group .Results VAS of the two groups decreased after treatment （P〈0 .05） ,group F decreased more significantly（P〈0 .05） .The quality of life scores after treatment in two groups were signifi-cantly increased（P〈0 .05） ,group F scoring was higher（P〈0 .05） .The incidence of side reaction ,nausea and vomiting was lower in group F（P〉0 .05） .The incidence of dysuria was 26 .67% in group T ,and there was no dysuria in group F（P〈0 .05） .Constipation of group T was 40% after treatment（P〈0 .05） .The incidence of somnolence of group F was higher than T group（P〈0 .05） .The two groups were no respiratory depression .Conclusion Fentanyl transdermal system for intractable postherpetic neuralgia has good analgesic effect ,less side effect ,and well-tolerated .
出处
《重庆医学》
CAS
CSCD
北大核心
2013年第33期4026-4027,共2页
Chongqing medicine
关键词
疱疹
带状
神经痛
芬太尼
镇痛
不良反应
herpes zoster
neuralgia
fentanyl
analgesia
side effect
