摘要
目的探讨胶体果胶铋颗粒联合替普瑞酮治疗慢性萎缩性胃炎的临床疗效。方法选取2015年7月—2016年2月在延安市人民医院接受治疗的慢性萎缩性胃炎84例,按照治疗方法差别分为对照组和治疗组,每组各42例。对照组口服替普瑞酮胶囊,1粒/次,3次/d。治疗组在对照组基础上口服胶体果胶铋颗粒,1袋/次,4次/d。两组患者均连续治疗4周。观察两组的临床疗效,同时比较两组治疗前后临床症状积分、C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、氧化物歧化酶(SOD)、一氧化氮(NO)、丙二醛(MDA)、胃泌素-17(G-17)、胃蛋白酶原I(PGI)、胃蛋白酶原II(PGII)的变化情况。结果治疗后,对照组和治疗组的总有效率分别为76.19%、92.86%,两组比较差异有统计学意义(P<0.05)。治疗后,两组胃刺痛评分、倦怠乏力评分、胃脘胀满评分、食少纳呆评分均显著降低,同组治疗前后差异有统计学意义(P<0.05);且治疗组治疗后这些评分低于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组CRP、IL-6、TNF-α、MDA水平明显低于同组治疗前,两组患者血清NO、SOD、G-17、PGI、PGII水平明显高于同组治疗前,同组治疗前后差异有统计学意义(P<0.05);治疗组治疗后这些观察指标的改善程度优于对照组,两组比较差异有统计学意义(P<0.05)。结论胶体果胶铋颗粒联合替普瑞酮治疗慢性萎缩性胃炎效果显著,可明显改善患者的临床症状,降低血清炎性因子水平,改善机体氧化应激状态及G-17、PGI、PGII水平,具有一定的临床推广应用价值。
Objective To investigate the effect of Colloidal Bismuth Pectin Granules combined with teprenone in treatment of chronic atrophic gastritis. Methods Patients（84 cases） with chronic atrophic gastritis in Yan＇an People＇s Hospital from July 2015 to February 2016 were divided into control and treatment groups based on different treatments, and each group had 42 cases. The patients in the control group were po administered with Teprenone Capsules, 1 grain/time, three times daily. The patients in the treatment group were po administered with Colloidal Bismuth Pectin Granules on the basis of the control group, 1 bag/time, four times daily. The patients in two groups were treated for 4 weeks. After treatment, the efficacy was evaluated, and the changes of clinical symptoms scores, CRP, IL-6, TNF-α, SOD, NO, MDA, G-17, PGI, and PGII in two groups before and after treatment were compared. Results After treatment, the efficacies in the control and treatment groups were 76.19% and 92.86%, respectively, and there were differences between two groups（P〈0.05）. After treatment, stomach stabbing pain scores, languid scores, diagnosis bilge full scores, eat less stay scores in two groups were significantly reduced, and the difference was statistically significant in the same group（P〈0.05）. And those scores in the treatment group were lower than those in the control group, with significant difference between two groups（P〈0.05）. After treatment, the levels of CRP, IL-6, TNF-α, and MDA in the two groups were significantly reduced, and levels of NO, SOD, G-17, PGI, and PGII were significantly increased, and the difference was statistically significant in the same group（P〈0.05）. The improvement of those observational indexes in the treatment group was better than those in the control group, with significant difference between two groups（P〈0.05）. Conclusion Colloidal Bismuth Pectin Granules combined with teprenone has clinical curative effect in treatment of chronic atrophic gastritis, and can obviously improve the clinical symptoms, and lower the levels of serum inflammatory factors, also can improve the oxidative stress state and levels of G-17, PGI, PGII, which has a certain clinical application value.
出处
《现代药物与临床》
CAS
2016年第11期1741-1745,共5页
Drugs & Clinic
