摘要
目的探讨奥美拉唑三联与四联疗法治疗幽门螺杆菌(Hp)阳性胃炎的临床效果。方法选择2021年5月—2023年5月巨野县中医医院收治的120例Hp阳性胃炎患者为研究对象,以随机数表法分为对照组和观察组,每组60例。对照组采用奥美拉唑三联疗法治疗,观察组采用奥美拉唑四联疗法治疗。比较两组患者的疗效、血清炎症因子水平、胃泌素族指标水平及不良反应发生情况。结果观察组的治疗总有效率为96.67%,高于对照组的83.33%,差异有统计学意义(P<0.05)。治疗后,观察组的C反应蛋白、降钙素原、肿瘤坏死因子-α、白细胞介素-6水平均低于对照组,组间差异有统计学意义(P<0.05)。治疗后,观察组的胆囊收缩素、胃泌素水平均低于对照组,胃动素、胃泌素17水平均高于对照组,组间差异有统计学意义(P<0.05)。两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论采用奥美拉唑四联疗法治疗Hp阳性胃炎的效果更理想,安全性更高。
Objective To investigate the clinical effect of omeprazole triple therapy and quadruple therapy in the treatment of helicobacter pylori(Hp)positive gastritis.Methods 120 patients with Hp positive gastritis admitted to Juye County Traditional Chinese Medicine Hospital from May 2021 to May 2023 were selected as the research objects,and were divided into a control group and an observation group by random number table method,with 60 cases in each group.The control group was treated with omeprazole triple therapy,and the observation group was treated with omeprazole triple therapy.The therapeutic effect,serum inflammatory factor levels,gastrin group index levels and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 96.67%,which was higher than 83.33%of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of Creactive protein,procalcitonin,tumor necrosis factor-αand interleukin-6 in the observation group were lower than those in the control group,the differences between the groups were statistically significant(P<0.05).After treatment,the levels of cholecystokinin and gastrin in the observation group were lower than those in the control group,and the levels of motilin and gastrin 17 were higher than those in the control group,the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The use of omeprazole quadruple therapy for the treatment of Hp positive gastritis has a more ideal effect and higher safety.
作者
李秋
LI Qiu(Department of Spleen and Stomach Diseases,Juye County Traditional Chinese Medicine Hospital,Heze Shandong,274900,China)
出处
《反射疗法与康复医学》
2024年第7期58-61,共4页
Reflexology And Rehabilitation Medicine
关键词
胃炎
幽门螺杆菌阳性
奥美拉唑
三联疗法
四联疗法
治疗效果
不良反应
Ggastritis
Helicobacter pylori positive
Omeprazole
Triple therapy
Quadruple therapy
Therapeutic effect
Adverse reaction
