摘要
目的探讨乌司他丁联合连续性血液净化在严重脓毒血症患者中的应用价值。方法选取我院2013年7月-2015年7月收治的40例重症脓毒血症患者作为研究对象,将所有患者根据随机数字表法分为对照组和研究组,每组20例,对照组患者单用连续性血液净化治疗,研究组患者在对照组的基础上联合乌司他丁治疗,对比两组患者治疗前后炎症介质浓度变化及临床转归。结果治疗前两组患者的炎症介质浓度比较无显著性差异,治疗后研究组炎症介质IL-6和TNF-α浓度低于对照组,两组比较,差异有统计学意义（P〈0.05）,治疗后研究组患者存活19例（占95.00%）,病死1例（占5.00%）,对照组患者存活15例（占75.00%）,病死5例（占25.00%）,两组比较,差异有统计学意义（P〈0.05）。结论乌司他丁联合连续性血液净化治疗严重脓毒血症,能有效的提高生存率,降低炎性细胞数量。
Objective To investigate the effects of ulinastatin combined with continuous blood purification and application value in patients with severe sepsis. Methods 40 cases of severe sepsis patients in our hospital from July 2013 to July 2015 as the object of study, all patients were randomly divided into control group and study group, 20 cases in each group, the control group was treated with continuous blood purification treatment, the study group patients in the control group on the basis of the treatment combined with ulinastatin, the changes of the concentration of inflammatory mediators and clinical outcomes were compared between the two groups before and after treatment. Results There was no significant difference between the two groups before treatment. After treatment, the levels of IL-6 and TNF- in the study group were lower than those in the control group, the difference was statistically significant（P0.05）, After treatment, patients in the study group 19 cases survived（95.0%）, 1 cases died（5.0%）, the control group with 15 cases survived（75.0%）, 5 cases died（25.0%）, the two groups, the difference was statistically significant（P0.05）. Conclusion Ulinastatin combined with continuous blood purification treatment of severe sepsis, can effectively improve the survival rate, reduce the number of inflammatory cells.
出处
《中国继续医学教育》
2016年第31期149-150,共2页
China Continuing Medical Education
