摘要
目的 探讨二代杂交捕获技术（HC2）与液基细胞学检测（TCT）对于宫颈癌早期筛查的临床价值。方法选取2013-2015年体检的已婚妇女1180例,均进行HC2与TCT联合检查,检查结果为阳性患者进行宫颈组织病理学检查。结果 1180例受检者TCT检查未明确诊断非典型鳞状上皮细胞（ASCUS）141例,低等级宫颈鳞状上皮病变（LSIL）177例,高等级宫颈鳞状上皮病变（HSIL）38例,宫颈鳞状细胞癌（SCC）19例;HC2检查HPV感染共465例。HC2检查方法对CINⅡ＋CINⅢ与宫颈浸润癌的检出率（82.61%）明显高于TCT检查方法（72.46%）,差异有显著性（P〈0.05）。TCT与HC2联合检查的检出率（95.65%）明显高于两种方法单独检测（P〈0.05）。结论 宫颈癌早期筛查中选择HC2与TCT联合检查方式能够有效提高疾病检出率,阳性患者患病危险性高,需病理活检进行确诊。
Objective To explore the clinical significance of applying HC2 combined with TCT in early screening of cervical cancer. Methods A total of 1180 married women examined in this hospital during 2013 to 2015 were selected, and they had received the examination of HC2 combined with TCT. Patients with positive results further received pathological examination of cervical tissue samples. Results Among these 1180 women, there were 141 cases with ASCUS, 177 cases with LSIL, 38 cases with HSIL, 19 eases with SCC and 465 eases with HPV infection. The detection rates of HC2 （82.61% ） for CIN II ＋ CIN III and invasive cervical cancer were evidently higher than those of TCT（72.46% ）, and the difference was significant （ P 〈 0.05 ）. The detection rate of TCT combined with HC2 （95.65 % ） was evidendy higher than that of single examination （ P 〈 0.05 ）. Conclusion The application of HC2 combined with TCT for early screening of cervical cancer can significantly raise their detection rate. The patients with positive results have higher risk for suffering from the disease, and they need biopsy for pathological diagnosis.
出处
《临床和实验医学杂志》
2016年第22期2272-2275,共4页
Journal of Clinical and Experimental Medicine
