摘要
目的 探讨术前血小板计数与结直肠癌患者预后的关系。方法 选取2009年1月~2012年4月在我院胃肠外科进行手术治疗的210例结直肠癌患者作为研究对象,分析术前血小板计数与临床病理资料的关系,并在术后进行随访。使用Log-rank检验、Cox单因素和多因素分析对影响结直肠癌患者预后的因素进行分析。结果 210例结直肠癌患者中,有74例（35.2%）患者发现术前的血小板计数升高（〉300×10~9/L）。术前血小板计数增高的发生率与TNM分期、T分期、N分期和M分期显著相关（P均〈0.05）。Log-rank检验提示术前高血小板水平组患者的术后生存率明显低于正常水平的患者（χ~2=9.994,P=0.002）。Cox单因素分析显示,TNM分期、T分期、N分期、M分期、脉管侵犯、外周神经侵犯、血清CEA水平和术前血小板计数是影响结直肠癌患者预后的因素。Cox多因素分析结果显示,TNM分期、N分期、M分期和术前血小板计数是结直肠癌患者预后的独立影响因素。结论 术前血小板计数增高是结直肠癌患者不良预后的高危因素,可作为预测结直肠癌患者预后的一项重要指标。
Objective To investigate the relationship between preoperative platelet count and prognosis of patients with colorectal cancer （CRC）. Methods 210 CRC patients underwent surgery in our hospital from January 2009 to April 2012 were selected as the study objects. The association between preoperative platelet count and clinicopathological features was analyzed, and the following-up was performed for their survival outcomes. Log-rank test, univariate and multivariate analysis of Cox proportional hazard model were used to find out the prognostic factors of CRC patients. Results Among the 210 CRC patients, there were 74 patients （35.2%） with high level of preoperative platelet count （ 〉 300＆#215;109/L）. The incidence of high preoperative platelet count was associated with TNM stage, depth of tumor invasion （T）, lymph node metastasis （N）, and distant metastasis （M） （P 〈 0.05）. Log-rank test indicated that the survival rate of CRC patients with high level of preoperative platelet count was significantly lower than that with normal level （χ2= 9.994, P =0.002）. Univariate analysis showed that TNM stage, depth of tumor invasion （T）, lymph node metastasis （N）, distant metastasis （M）, vascular invasion, perineural invasion, serum CEA, and preoperative platelet count were influencing factors for prognosis of CRC patients. Multivariate analysis showed that TNM stage, depth of tumor invasion （T）, lymph node metastasis （N）, distant metastasis （M）, and preoperative platelet count were independent prognostic factors for CRC patients. Conclusion High level of preoperative platelet count is a high-risk factor for poor prognosis in CRC patients. Preoperative platelet count can be an important index for predicting prognosis of CRC patients.
出处
《中国医药科学》
2016年第17期133-137,共5页
China Medicine And Pharmacy
关键词
术前血小板计数
结直肠癌
预后
临床病理资料
Preoperative platelet count
Colorectal cancer
Prognosis
Clinicopathological features
