摘要
目的：本研究旨在通过流行病学研究探讨并分析高同型半胱氨酸血症（HHcy）与动脉硬化相关疾病的关系.方法 采用分层、分段、随机、整群的抽样调查方法,抽取北京城乡1460例60岁及以上老年人（男638例,女822例）作为调查对象.采用调查问卷、体格检查的形式获得样本人群动脉硬化相关疾病的患病情况,通过抽血化验测定血浆Hcy水平,并统计分析HHcy与动脉硬化相关疾病的关系.结果 HHcy与高血压（x2=19.064,P＜ 0.01）、冠心病（x2=12.039,P＜0.05）、脑血管病（x2=10.947,P＜0.05）、糖尿病（x2=20.843,P＜ 0.01）、认知功能异常（x2=12.402,P＜0.05）的患病相关.结论 HHcy与高血压、冠心病、脑血管疾病、糖尿病、认知功能异常的患病率有相关性.Hcy≥10μmol/L增加动脉硬化相关疾病的患病风险.
Objective This paper is aimed to study the relationship between Hyperhomocysteinemia （HHcy） and atherosclerosis-related diseases through epidemiological studies. Methods This research investigated 1460 individuals older than 60 years （638male, 822 female） from urban and rural area of Beijing. We collected the situation of atherosclerosis-related disease in samples by using questionnaires and physical examination, then measured the levels of plasma Homocysteine（Hcy） by blood test. The relationship between HHcy and atherosclerosis-related diseases was analyzed. Results HHcy significantly affected the prevalence of atherosclerosis- related disease, such as hypertension, coronary heart disease, cerebrovascular diseases, diabetes and cognitive dysfunction.（hypertension X2=19.064, P〈0.01）;（coronary heart disease X2=12.039, P〈0.05）;（cerebrovascular disease X2=10.947, P〈0.05）;（diabetes x2=20.843, P〈0.01）;（cognitive dysfunction X2=12.402, P〈0.05）. Conclusion Hcy levels higher than 10 mol/L increases the risk of atherosclerosis-related diseases.
作者
李理
汤哲
孙菲
刁丽君
王建平
马丽娜
张丽
Li Li Tang Zhe Sun Fei Diao Lijun Wang Jianping Ma Lina Zhang Li(Department of Social Medicine, Xuan Wu Hospital, Capital Medical University Beijing 100053, China)
出处
《北京医学》
CAS
2016年第10期980-983,共4页
Beijing Medical Journal
基金
卫生部行业基金科研专项基金资助项目(201002011)
