摘要
近年来提出了一种新的细胞死亡类型,即程序性坏死,与细胞坏死具有相同的形态学特征,又与细胞凋亡有着相似的生物学特点,有其独特的信号传导通路。已有多项研究证实程序性坏死在炎症、缺血再灌注损伤、肿瘤等的发生发展中起到了重要的作用。恶性血液病是一组高度恶性、预后差的造血系统疾病。本综述总结程序性坏死的信号通路及其在恶性血液病中作用的研究进展。
Necroptosis is a novel programmed cell death mechanism which is characterized by a necrotic morphology,but the necroptosis is precisely regulated by cellular signaling pathway just like apoptosis.Recently,many reports have revealed that necroptosis contributes to the pathogenesis of inflammation,ischemic reperfusion injury and tumour.Hematological malignancies are a set of hemotopathy diseases with poor prognosis.In this review,the research progress of signaling pathway of necroptosis and its role in hematological malignancies are summarized.
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2016年第5期1588-1593,共6页
Journal of Experimental Hematology
