摘要
目的分析男性2型糖尿病(T2DM)并发白蛋白尿但肾功能正常患者的骨密度(BMD)变化。方法本研究为回顾性分析,纳入202例肾功能正常的男性T2DM患者和99例男性健康对照者(A组)。T2DM患者根据尿白蛋白与肌酐比值(UACR)分为正常白蛋白尿组(B组)、微量白蛋白尿组(C组)及大量白蛋白尿组(D组)。采用双能X线吸收法(DXA)测量所有受试者腰椎及髋部BMD值。结果 B组、C组腰椎BMD较A组升高(P<0.05);D组腰椎BMD较A有升高趋势,较B组、C组间有降低趋势,但差异均无统计学意义(P>0.05)。大转子区(Troch)、转子间区(Inter)、髋部总体区(Total Hip)BMD在B组、C组较A组升高(P<0.05),在D组较A、B、C组间均有升高趋势,但差异无统计学意义(P>0.05)。股骨颈区(Neck)、Ward三角区(Ward)BMD在4组间差异无统计学意义(P>0.05)。L1-4BMD和Total Hip BMD在C较B组有升高趋势,但差异无统计学意义(P>0.05)。结论男性T2DM患者BMD较健康人群升高,并发微量白蛋白尿时BMD可能继续升高,出现大量白蛋白尿后腰椎BMD有回降趋势,而髋部BMD有进一步升高趋势。
Obje ctive To analyze the change of bone mineral density（ BMD） in male type 2 diabetes mellitus（ T2DM） patients with normal renal function complicated with albuminuria. Me thods The study is a retrospective analysis,202 male T2 DMpatients with normal renal function and 99 male healthy controls（ group A） were enrolled. According to a urine albumin-to-creatinine ratio（ UACR）,T2 DMpatients were categorized into three groups： normal albuminuria group（ group B）,microalbuminuria group（ group C） and macroalbuminuria group（ group D）. BMD were measured by dual energy X-ray absorptiometry（ DXA）. Results BMD of lumbar spine in group B and group C was higher than that in group A（ P 〈 0. 05）,and this parameter in group D had a non-significant trend of higher than that in group A（ P 〉 0. 05） but lower than that in group B and group C（ P 〉 0. 05）. BMD of Trochanter,Intertrochanter and Total Hip in group B and group C was higher than that in group A（ P 〈 0. 05）,and this parameter in group D had a non-significant trend of higher than that in group A,group B and group C（ P 〉 0. 05）. BMD of lumbar and Total Hip in group C had a non-significant trend of higher than that in group B（ P 〉 0. 05）. Conclusion BMD of male T2 DMpatients was higher than that of healthy population,and it may continue to increase with appearance of microalbuminuria. However,BMD of lumbar spine may begin to decrease and BMD of hip may continue to increase after emergence of macroalbuminuria.
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2016年第10期1293-1297,共5页
Chinese Journal of Osteoporosis
关键词
2型糖尿病
男性
白蛋白尿
骨密度
Type 2 diabetes mellitus
Male
Albuminuria
Bone mineral density
