摘要
目的:探讨绝经后女性2型糖尿病(T2DM)患者腰椎骨髓脂肪分数(FF)与骨密度(BMD)的相关性。方法:绝经后T2DM患者(T2DM组,年龄49~85岁,n=43)及正常健康对照组(年龄50~77岁,n=35)行双能X线吸收测量法及磁共振波谱扫描,获取腰椎BMD及L3椎体FF。检测受试者空腹血糖(FPG)、糖化血红蛋白(Hb A1c)、胰岛素(FINS)及血脂指标,利用稳态模型计算胰岛素抵抗指数(HOMA-IR)。结果:T2DM组腰椎BMD[(1.103±0.187)g/cm^2]及FF(74.1%±16.7%)与正常对照组[BMD为(1.015±0.171)g/cm^2,FF为63.3%±12.9%]比较明显升高。将绝经年数、BMI、FPG、Hb A1c、HOMA-IR、血脂指标及BMD作为协变量加以校正,T2DM组FF仍较正常对照组高(F=10.857,P=0.010)。偏相关分析校正上述影响因素,正常对照组FF与BMD仍存在负相关性(r=-0.430,P=0.014),而T2DM组FF与BMD存在正相关性(r=0.385,P=0.029)。结论:绝经后T2DM患者虽具有较高的BMD值,但其骨髓脂肪含量是增高的。
Objective： To explore the relationship between vertebral bone density （BMD） and marrowfat fraction （FF） in postmenopausal females with type 2 diabetes （T2DM）. Methods： Patients with T2DM （49- 85 years, n=43） and healthy controls （50-77 years, n=35） underwent DXA and MR spectroscopy scanning to obtain BMD and FF. Blood glucose （FPG）, HbAlc, fasting insulin （FINS） and total cholesterol （TC）, triglycer- ides （TG）, high-density lipoprotein cholesterol （HDL-C） and low-density lipoprotein cholesterol （LDL-C） were measured after fasting for 12 h. Homeostasis model assessment was performed to assess the status of insulin resistance （HOMA-IR）. Results： Subjects with T2DM had higher vertebral BMD [（1.103±0.187）g/cm2] and FF （74.1%± 16.7%） than those of healthy controls [BMD=（1.015±0.171 ） g/cm2, FF=63.3 %±12.9%, respectively]. Even controlling for years of menopause, BMI, FPG, HbAlc, HOMA-IR and blood lipids index, FF in the T2DM group remained higher than that in the control group （F=10.857, P=0.010）. FF was inversely correlated to BMD in the control group （r=-0.430, P=0.014） but positively associated with BMD in the T2DM group （r=0.385, P=-0.029） after adjustment for the confounders. Conclusion： Despite having higher BMD values, patients with T2DM in postmenopausal females have higher vertebral marrow fat content.
出处
《温州医科大学学报》
CAS
2016年第1期28-32,共5页
Journal of Wenzhou Medical University
基金
温岭市科技局科研基金资助项目(2010WLCB0085)
