摘要
肝细胞癌(hepatocellular carcinoma,HCC)是一种很常见的恶性肿瘤,流行病学和临床病理学研究发现其多发生在肝脏原有病变的基础上。在中国,长期慢性的乙型肝炎病毒(hepatitis B virus,HBV)感染是HCC发生的主要危险因子。肿瘤干细胞(cancer stem cell,CSC)理论认为HCC的起始细胞(tumor initial cell,TIC)是CSC,但其中的机制尚不明确,特别是CSC在HBV相关HCC发生和发展中的作用。本文就肿瘤干细胞在HBV相关HCC发病中的机制及CSC标志物在临床诊疗和预后评估等方面的最新研究进展作一总结。
Hepatocellular carcinoma（HCC）is one of the most common malignant tumors worldwide.Epidemiological and clinicopathological analyses indicated that HCC mostly occurred on previous liver diseases,of which chronic infection of hepatitis B virus（HBV）was the main risk factor in China.The cancer stem cell（CSC）theory believed that CSCs were tumor initial cells（TICs）of HCC.So far,the association of CSCs with HBV-related HCC,especially their roles in the development and progression of HCC,has not been illustrated clearly.This review focused on the recent progress in the mechanisms of CSCs in HBV-related hepatocarcinogenesis,as well as the biomarkers of CSCs in clinical diagnosis,treatment and prognosis analyses.
出处
《复旦学报（医学版）》
CAS
CSCD
北大核心
2016年第5期610-614,共5页
Fudan University Journal of Medical Sciences
基金
国家自然科学基金人才培养项目(J1210041)~~
关键词
肿瘤干细胞
肝细胞癌
乙型肝炎病毒
cancer stem cell
hepatocellular carcinoma
hepatitis B virus
