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人乳头状瘤病毒相关口咽癌的病因和分子生物学及临床特征 被引量：3

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摘要 人乳头状瘤病毒（human papilloma virus,HPV）是宫颈癌的主要致病因素,病毒癌基因E6、E7编码的相关癌蛋白能促进细胞的p53蛋白产物降解,抑制Rb蛋白功能,影响细胞周期调控,从而导致肿瘤发生[1].70%宫颈癌可归因于HPV中的致瘤高危株HPV-16、HPV-18的感染[2].自从1985年首次报道在口腔癌中检出HPV以来[3],喉、口咽、下咽等多个部位的鳞癌中均检出HPV存在,而口咽癌的阳性率明显高于其他头颈部鳞癌,达36%-57%,其中绝大部分为HPV-16株[4-5].HPV相关的口咽癌在西方国家呈逐年上升趋势[6-7],其独特的病因、分子生物学和临床特征引起了越来越多的关注.
作者 吴润叶 高黎
机构地区 中国医学科学院北京协和医学院肿瘤医院肿瘤研究所放疗科
出处 《中华放射肿瘤学杂志》 CSCD 北大核心 2010年第4期378-380,共3页 Chinese Journal of Radiation Oncology
关键词 人乳头状瘤病毒 分子生物学 致病因素 临床特征 口咽癌 HPV-16 细胞周期调控 头颈部鳞癌
分类号 R686 [医药卫生—骨科学]
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参考文献37

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  • 2Cox JT.The development of cervical cancer and its precursors:what is the role of human papillomavirus infection? Curr Opin Obstet Gynecol,2006,18:5-13.
  • 3Loning T,Ikenberg H,Becker J,et al.Analysis of oral papillomas,leukoplakias,and invasive carcinomas for human papillomavirus type related DNA.J Invest Dermatol,1985,84:417-420.
  • 4Kreimer AR,Clifford GM,Boyle P,et al.Human papillomavirus types in head and neck squamous cell carcinomas worldwide:asystematic review.Cancer Epidemiol Biomarkers Prev,2005,14:467-475.
  • 5Gillison ML,Koch WM,Capone RB,et al.Evidence for a causal association between human papillomavirus and a subset of head and neck Cancers.J Natl Cancer Inst,2000,92:709-720.
  • 6N(a)sman A,Attner P,Hammarstedt L,et al.Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm,Sweden:an epidemic of viral-induced carcinoma? Int J Cancer,2009,125:362-366.
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  • 8Begum S,Cao D,Gillison ML,et al.Tissue distribution of human papillomavirus 16 DNA integration in patients with tonsillar carcinoma.Clin Cancer Res,2005,11:5694-5699.
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  • 10Kim SH,Koo BS,Kang S,et al.HPV integration begins in the tonsillar crypt and leads to the alteration of p16,EGFR and c-myc during tumor formation.Int J Cancer,2007,120:1418-1425.

同被引文献36

  • 1张洁莉,孙昭,霍真,罗玉凤,马水清,王德田,曹金伶,杨缇,崔全才,白春梅.头颈部鳞癌人乳头状瘤病毒16/18感染状态与Ki-67、P53表达的关系[J].中国医学科学院学报,2010,32(4):429-432. 被引量：14
  • 2王树森,管忠震,向燕群,汪波,林桐榆,姜文奇,张力,张惠忠,侯景辉.鼻咽癌组织中EGFR和p-ERK蛋白表达的检测及意义[J].中华肿瘤杂志,2006,28(1):28-31. 被引量：47
  • 3Syrjanen S. Human papillomavirus (HPV) in head and neck cancer. J Clin Virol, 2005,32( Suppl 1 ) : 59-66.
  • 4Cleveland JL, Junger ML, Saraiya M, et al. The connection between human papillomavirus and oropharyngeal squamous cell carcinomas in the United States: implications for dentistry. J Am Dent Assoc, 2011,142: 915-924.
  • 5Heck JE, Berthiller J, Vaccarella S, et al: Sexual behaviours and the risk of head and neck cancers: a pooled analysis in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Int J Epidemiol, 2010,39: 166-181.
  • 6Ragin CC, Taioli E. Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: Review and meta analysis. Int J Cancer, 2007,121 : 1813-1820.
  • 7Tang X, Jia L, Ouyang J, et al. Comparative study of HPV prevalence in Japanese and North-east Chinese oral carcinoma. J Oral Pathol Med, 2003,32 : 393-398.
  • 8冯淑瑜,张彦娜,刘继红,刘建刚,严鸣.宫颈癌和宫颈上皮内瘤变中表皮生长因子受体表达与人乳头瘤病毒16和(或)18感染及其相互关系[J].中华肿瘤杂志,2007,29(10):759-763. 被引量：10
  • 9Gillison ML,Koch WM,Capone RB. Evidence for a causal association between human papillomavirus and a subset of head and neck cancers[J].{H}JOURNAL OF THE NATIONAL CANCER INSTITUTE,2000,(9):709-720.
  • 10Argiris A,Karamouzis MV,Raben D. Head and neck cancer[J].{H}LANCET,2008,(9625):1695-1709.

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中华放射肿瘤学杂志
2010年 第4期

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