摘要
近年来大剂量甲氨蝶呤作为预防急性淋巴细胞白血病髓外浸润的重要手段,很大程度降低了中枢神经系统白血病的发生,从而提高了儿童长期无病生存率,其有效性得到了国内外学者的充分肯定。因此,国内外学者都致力于研究HDMTX-CF方案。本文将从疾病的流行病学、药物作用机制、不良反应、治疗方案现状、治疗药物监测等方面进行综述。
In recent years,high-dose methotrexate is an important measure to prevent acute lymphoblastic leukemia,which greatly reduces occurrence of central nervous system leukemia to improve long-term disease-free survival rate in children.Its effectiveness has been fully affirmed by domestic and foreign scholars.Therefore,scholars both at home and abroad have devoted themselves to researches of HDMTX-CF project.This article will review epidemiology of diseases,mechanism of drug action,adverse drug reaction,current treatment status,therapeutic drug monitoring and so on.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2016年第18期1613-1618,共6页
Chinese Journal of Hospital Pharmacy
