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大剂量甲氨蝶呤对神经系统毒性反应的研究进展 被引量：2

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作者 沈向梅 何雯 张瑛 李玲
机构地区 昆明医学院附属医院儿科
出处 《陕西医学杂志》 CAS 2009年第1期112-114,共3页 Shaanxi Medical Journal
基金 昆明医学院硕士研究生创新性基金项目(NoKM2007L31)
关键词 神经系统毒性反应 大剂量甲氨蝶呤 急性淋巴细胞性白血病 二氢叶酸还原酶 胃肠道黏膜损伤 叶酸拮抗药 成神经细胞瘤 抑制作用
分类号 R978.11 [医药卫生—药品] R733.71 [医药卫生—肿瘤]
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参考文献18

  • 1Seitz M. Molecular and cellular effects of methotrexate. Current Opinion in Rheumatology, 1999, 11 (3) : 226- 232.
  • 2Hum MC, Smith AK , Lark RH, et al. Evidence for negative feed-backof extracellular methotrexate on blasts of acute lymphoblastic leukemiain vitro. Pharmacotherapy, 1997,17(6) : 1260-1266.
  • 3Rask C, AIbertioni F, Bentzen SM, et al. Clinical and pharmacokinetic risk factor for high-dosemethotrexate induced toxicity in children with acute lymphoblastic leukemia[J].Acta Oncologica, 1998,37 (3) : 278-284.
  • 4Evans WE, Relling MV, Boyett JM, et al. Does phamacokinetic variabilicy influence the efficacy of high dose methotrexate for the treatment of children with acute lymphoblastic leukemia: what can welearnfrom small studies[J]. Leuk Res, 1997,21 (5) : 435-437.
  • 5Odoul F,Le Guellec C, Lamagnere JP, et al. Prediction of methotrexate elimination after high dose infusion in children with acute lymphoblastic leukemia using a population pharmacokinetic approach. Fundam Clin Pharmacol, 1999,13(5):595-604.
  • 6Mc-Crudden EA, Tett SE. Improved high-performance liquid chromatog-raphy determination of methotrexate and its major metaholite in plasma using a poly (styrenedivinylbenzene) column [J]. J Chromatogr Biomed Sci Appl, 1999,721(1): 87.
  • 7Masson S Relling MV, Synold TW, et al. Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant antileukemic effects in vivo[J]. J Clin Invest, 1996,97 (1) : 73-80.
  • 8Vezmar S, Becker A, Bode U, et al. Biochemical and clinical aspects of methotrexate neurotoxicity. Chemotherapy,2003 ,49(1-2) :92-104.
  • 9Keime-Guibert F, Napolitano M, Delattre JY. Neurological complications of radiotheraphy and chemotheraphy. J Neurol, 1998,245 : 695-708.
  • 10Paakko E, Harila-Saari A, Vanionpaa L, et al. White matter changes on MRI during treatment in children with acute lymphoblastic leukemia: correlation with neuropsychological findings. Med Pediatr Oncol, 2000, 35:456-461.

同被引文献18

  • 1Ruhnitz JE,Relling MV, Harrison PL, et al. Transient encephalopathy following high-dose methotrexate treatment in childhood acute lymphoblastic leukemia[J]. Leukemia, 1998,12(8) : 1176-1181.
  • 2Inaba H, Khan RB, Laningham FH, et al. Clinical and radiological characteristics of methotrexate-induced acute encephalopathy in pediatric patients with cancer[J]. Ann Oncol,2008,19(1) ..178-184.
  • 3Vezmar S,Becker A,Bode U,et al. Biochemical and clinical aspects of methotrexate neurotoxicity[J]. Chemotherapy,2003,49(1/2) ..92-104.
  • 4Miketova P,Kaemingk K, Hockenberry M, et al. Oxidative changes in cerebral spinal fluid phosphatidylcholine during treatment for acute lymphoblastic leukemia[J]. Biol Res Nurs,2005,6(3):187-195.
  • 5Haykin M, Gorman M,van Hoff J, et al. Diffusion-weighted MRI correlates of subacute methotrexate-related neurotoxicity[J]. J Neurooneol,2006,76(2) : 153-157.
  • 6Price S. Diffusion-Weighted Mr imaging of the brain[J]. Radiology, 2006,148 (5) : 600.
  • 7Fisher MJ, Khademian ZP, Simon EM, et al. Diffusionweighted Mr imaging of early methotrexate-related neurotoxicity in children[J]. AJNR Am J Neuroradiol,2005, 26(7) .. 1686-1689.
  • 8张绪梅,黄国伟,田志红,任大林.甲氨蝶呤对体外培养神经干细胞的毒性作用[J].天津医药,2009,37(4):292-294. 被引量：1
  • 9许静,徐康康.甲氨蝶呤神经系统毒性研究进展[J].中国药房,2010,21(2):176-179. 被引量：11
  • 10孟岩,梁筱灵,宪莹,王刚,苏庸春,肖剑文,温贤浩,于洁.大剂量甲氨蝶呤治疗儿童急性淋巴细胞白血病的安全性与疗效分析[J].儿科药学杂志,2010,16(5):7-11. 被引量：31

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陕西医学杂志
2009年 第1期

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