摘要
目的探讨难治性癔球症(RG)与非难治性癔球症(NRG)患者食管运动功能尤其是食管上括约肌(UES)压力及血清脑肠肽水平的变化特征。方法采用高分辨食管测压系统(HRM)对癔球症患者行食管测压并留取空腹静脉血,检测血清脑肠肽水平,对比难治性癔球症患者和非难治性癔球症患者食管测压结果及血清脑肠肽水平差异。结果 RG患者的UES静息压显著高于NRG患者[(94.97±42.08)mmHg,(73.91±23.47)mmHg,t=2.359,P<0.05)](1 mmHg=0.133 kPa);RG患者与NRG患者UES残余压[(12.44±8.31)mmHg,(12.66±8.12)mmHg]、UES长度[(22.72±10.13)mm,(19.71±7.85)mm]、收缩前速度(CFV)[(5.47±1.39)cm/s,(5.24±1.40)cm/s]、收缩延迟时间(DL)[(6.59±1.29)s,(6.78±1.10)s]、食管下括约肌(LES)静息压[(22.63±10.17)mmHg,(19.56±7.63)mmHg]比较,均差异无统计学意义(t=0.528,0.471,0.725,0.736,0.486;P>0.05);NRG患者的血清神经肽Y(NPY)水平较RG患者低[(626.26±16.60)ng/L,(641.35±17.45)ng/L,t=2.528,P<0.05];RG患者血清P物质(SP)水平高于NRG患者[(2386.96±372.68)ng/L,(1607.77±345.91)ng/L,t=3.728,P<0.05)];NRG患者与RG患者两者血清中降钙素基因相关肽(CGRP)水平无统计学差异[(236.17±76.85)ng/L,(229.35±57.52)ng/L,t=0.752,P>0.05)]。结论相对于NRG患者,RG患者具有更高的UES静息压和较高水平的血清P物质含量以及较低水平的血清神经肽Y含量。
Objective To compare the esophageal motility and the levels of brain-gut peptide between refractory globus patients and non-refractory globus patients.Methods All subjects underwent high-resolution manometry （HRM） and were detected the levels of brain-gut peptide,which were compared the differences between refractory globus patients and non-refractory globus patients.Results Refractory globus patients had higher upper esophageal sphincter （UES） resting press [（94.97±42.08）mmHg] compared with non-refractory globus patients [（73.91±23.47） mmHg, t =2.359, P 〈0.05].There were no statistical differences in UES residual pressure[（12.44±8.31） mmHg,（12.66±8.12） mmHg],UES length[（22.72± 10.13）mm,（19.71±7.85）mm],CFV[（5.47±1.39）cm/s,（5.24±1.40）cm/s],DL[（6.59±1.29）s,（6.78± 1.10）s],LES[（22.63±10.17）mmHg,（19.56±7.63）mmHg] between refractory globus patients and non-refractory globus patients （t =0.528,0.471,0.725,0.736,0.486;P〉0.05）.The level of NPY was lower in refractory globus patients [（626.26±16.60）ng/L] than that in non-refractory globus patients [（641.35± 17.45）ng/L （t =2.528,P〈0.05）],but the level of SP was higher in refractory globus patients [（2386.96± 372.68）ng/L] than that in non-refractory globus patients [（1607.77±345.91） ng/L],the difference was＆amp;nbsp;statistically different （t =3.728, P〈0.05） .And no statistical difference was found in calcitonin gene-related peptide （CGRP） between refractory globus patients and non-refractory globus patients （t=0.752, P〉0.05）. Conclusion Compared with non-refractory globus patients, refractory globus patients have higher UES resting pressure,higher level of SP and lower level of NPY.
出处
《中华诊断学电子杂志》
2016年第3期149-152,共4页
Chinese Journal of Diagnostics(Electronic Edition)
关键词
癔球症
食管括约肌
上段
降钙素基因相关肽
神经肽Y
P物质
Globus
Esophageal sphincter,upper
Calcitonin gene-related peptide
Neuropeptide Y
Substance P
