摘要
正常水平的自噬是一种通过降解细胞内异常组分以维持细胞稳态的过程,然而自噬水平过度上调则引起细胞自噬性死亡;虽然,在生化代谢与形态学方面,自噬性细胞死亡与另两种细胞死亡形式—凋亡和坏死有明显的差别,但是,越来越多的研究表明这三者之间有着密切的联系;因而对于自噬及其和凋亡、坏死之间关系的深入研究对相关疾病的认识和治疗具有相当重要的意义。
Autophagy is a highly regulated intracelhilar degradative process by which cells remove cytosolic longlived proteins and damaged organelles. Although autophagy is regarded as a regular degradative process maintaining cellular homeostasis, this process also represents one mode of programmed cell death. Although there are significant differences between autophagic cell death, apoptosis and necrosis in the metabolic and morphologic changes,it is revealed that there are extensive crosstalks in autophagic cell death, apoptosis and necrosis. Therefore,it is important to investigate the relationship obetween autophagy, apoptosis and necrosis to provide clues for effective prevention and treatment of relevant diseases.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2016年第10期1433-1436,共4页
Chinese Journal of Public Health
基金
辽宁省高等学校科学研究一般项目(L2014354)
关键词
自噬
凋亡
坏死
溶酶体膜稳定性
autophagy
apoptosis
necrosis
lysosomal membrane stability
