摘要
目的系统评价干扰素治疗轮状病毒肠炎的有效性及安全性.方法计算机检索Pub Med,EMBASE,the Cochrane Library,CBM,CNKI,Wan Fang Data数据库,搜集干扰素治疗轮状病毒肠炎的相关随机对照试验(randomized controlled trials,RCT),检索时限均从建库至2016-04.由2位评价员独立筛选文献,提取资料并评价纳入研究的偏倚风险后,采用Revman5.2及Stata12.0软件进行Meta分析.结果共纳入22个RCT,共计2135例患儿.Meta分析结果显示:干扰素组的总有效率高于对照组(90.5%vs 66.4%,RR=1.33,95%CI:1.19-1.48,P<0.00001),退热时间[M D=-0.90,95%C I(-1.17-(-0.63),P<0.00001],止泻时间[MD=-1.66,95%CI:-2.10-(-1.22),P<0.00001],住院时间[MD=-1.46,95%CI:-1.83-(-1.08),P<0.00001]均短于对照组,差异有统计学意义;两组的不良反应发生率无统计学差异.结论干扰素在轮状病毒肠炎治疗中应用是一种有效和安全的新治疗方法,但受纳入研究质量的影响,仍需后续纳入高质量随机对照试验进一步证实.
AIM To systematically review the efficacy and safety of interferon for treating rotavirus enteritis.METHODS We searched the databases including PubMed,EMBASE,The Cochrane Library,CBM,CNKI,and WanFang Data for collecting randomized controlled trials（RCTs） about interferon for treating rotavirus enteritis from the inception of databases to April 2016.Two of the authors assessed trial eligibility and risk of bias,extracted and analyzed the data by using Revman5.2 and Statal2.0 software.RESULTS Twenty-two trials,enrolling 2135 children,met our inclusion criteria.The results of metaanalysis showed that,compared with the control group（conventional therapy group）,the interferon group had a higher total effective rate（RR = 1.33,95%CI：1.19-1.48,P 0.00001） and shorter time to fever relief[MD =-0.90,95%CI：-1.17-（-0.63）,P 0.00001],time to diarrhea relief[MD =-1.66,95%CI：-2.10-（-1.22）,P 0.00001],and length of hospital stay[MD =-1.46,95%CI：-1.83-（-1.08）,P 0.00001].There was no significant difference in the rate of adverse reactions between the two groups.CONCLUSION Using interferon to treat rotavirus enteritis is an effective and safe therapeutic method.However,with the impact of the quality of the included studies,our findings should be confirmed by more high-quality RCTs.
出处
《世界华人消化杂志》
CAS
2016年第26期3790-3798,共9页
World Chinese Journal of Digestology
