摘要
聚丁二酸丁二酯(PBS)因具备良好的物理性能和加工性能而备受关注,是最具有前途的生物降解材料之一。本文总结了PBS材料合成、共聚改性及其功能化方面的研究进展。无规共聚、嵌段共聚等方法可以调节材料的力学性能、生物降解性能、热性能和结晶行为。通过与聚富马酸丁二酯无规共聚或者嵌段共聚,可以利用分子链上的双键高效引入磺酸根、羧酸、氨基等基团,提高材料的亲水性和生物相容性能,并制备PH响应性的电荷翻转胶束,拓展PBS在生物医药领域的应用。
Poly（butylene succinate） （PBS） is one of the most promising members of biodegradable materials because of its good physical property and processability. In this review, progress on synthesis, copolymerization and functionalization of PBS has been summarized. The material＇s mechanical properties, biodegrability, thermal properties and crystallization behavior can be tuned by random copolymerization and block copolymerization. Sulfonate, carboxylate, amino have been introduced to improve the hydrophilicity and biocompatibility via the high-efficient reaction of the double bonds on poly （butylene fumarate） based random or block polymers. Micelles with pH-triggered reversible surface charges has been prepared. It has great potential to be used as intelligent drug delivery system for cancer therapy.
出处
《高分子通报》
CAS
CSCD
北大核心
2016年第9期115-125,共11页
Polymer Bulletin
基金
国家自然科学基金(Grant No.21574137
21104087
51373186)
中国科学院化学研究所培育项目(Grant No.CMS-PY-201239)
关键词
聚丁二酸丁二酯
共聚
力学性能
降解
功能化
Poly（butylene succinate）
Copolymerization
Mechanical propertiesi Biodegradation
Functionalization
