摘要
目的 探讨绝经后妇女骨髓脂肪含量与内脏脂肪（VAT）、皮下脂肪组织（SAT）及其比值的相关性。方法绝经后健康女性受试者37例（年龄50~68岁）行L3椎体单体素磁共振波谱扫描获得椎体骨髓脂肪分数（FF）,腹部（以L4为水平）横断位T1WI成像以定量VAT及SAT,并计算VAT/SAT。评价MRI两次重复扫描可重复性及不同观察者测量值的一致性,多元回归分析FF值的独立相关因素。结果 L3椎体FF值测量可重复性变异系数（CV）为2.86%,而SAT及VAT CV分别为1.45%、2.29%。不同观察者间测量SAT及VAT组内相关系数分别为0.962、0.935（P均〈0.001）。FF值与VAT（r=0.598）、SAT（r=-309）、VAT/SAT比值（r=492）、年龄（r=0.327）、绝经年数（r=0.401）、BMI（r=-0.332）存在一定相关性（P均〈0.05）。多元线性回归分析显示VAT（Sβ=0.417,P〈0.001）及VAT/SAT（Sβ=0.398,P=0.009）是FF值的独立负性相关因素。结论 绝经后女性骨髓脂肪含量与内脏脂肪组织有关。
Objective To explore the relationships of marrow fat content with visceral adipose tissue （VAT）, subcutaneous adipose tissue （SAT） and VAT/SAT in postmenopausal women. Methods Healthy postmenopausal women （ n = 37, 50 - 68 years） underwent single voxel MR spectroscopy for quantifying marrow fat fraction （FF） and T1WI at the L4 vertebral level to ob- tain VAT, SAT and their ratio. Ten participants were scanned twice to assess the reproducibility of FF measurements. The relia- bility of FF measurements was evaluated with the intra-class correlation coefficient （ICC）. Results The mean coefficients of variation of FF, SAT and VAT were 2.86% , 1.45% and 2.29% , respectively. According to the ICC, the measurements were reliable （ ICC =0. 962 for SAT and ICC = 0. 935 for VAT, all P 〈 0. 001 ）. FF was significantly correlated with VAT （ r = 0. 598）, SAT（ r =-309）, VAT/SAT ratio （ r =492）, age （ r =0. 327）, years since menopause （ r =0.401 ） and BMI （ r = - 0.332） （ all P 〈 0. 05 ）. Stepwise multiple regression analysis showed that VAT and VAT/SAT ratio were independent correla- tion factors of FF（ S/3 =0. 417, P 〈0. 001 andSfl =0. 398, P =0. 009）. Conclusion Marrow fat content was related to viscer- al adipose tissue in postmenopausal women.
出处
《医学影像学杂志》
2016年第9期1694-1697,共4页
Journal of Medical Imaging
关键词
磁共振成像
骨髓脂肪
内脏脂肪
皮下脂肪
MR Spectroscopy
Marrow fat
Visceral adipose tissue
Subcutaneous adipose tissue
