摘要
目的 观察艾灸对实验性 RA大鼠炎症局部炎症介质的影响。方法 麦粒灸佐剂性关节炎大鼠“肾俞”、“足三里”,采用荧光免疫、放射免疫方法检测炎症局部 5 -羟色胺 (5 - HT)、组胺 (HA )和前列腺素 E2 (PGE2 )含量。结果 造模后 ,5 - HT、HA、PGE2 含量均显著升高 (P<0 .0 1) ;艾灸治疗后 ,三者含量又显著降低 (P<0 .0 1) ;摘除肾上腺后艾灸 ,HA含量有显著性下降(P<0 .0 5 ) ,而 5 - HT、PGE2 含量下降不明显 (P>0 .0 5 )。结论 艾灸治疗可明显清除炎症局部组织中 5 - HT、HA、PGE2 ,从而减轻局部炎症反应、水肿、疼痛等症状。肾上腺在艾灸清除炎症介质过程中有明显作用。
Purpose To observe the effects of moxibustion on local inflammatory media in experimental RA rats. Method Moxibustion with grain-sized moxa cone was performed on points Shenshu and Zusanli in rats with adjuvant arthritis. The 5-hydroxytrptamine(5-HT),histamine(HA) and prostaglandin E 2(PGE 2) contents of local inflammatory tissues were measured by fluorescent immunoasssay and radioimmunoassay. Results After the model was made, 5-HT, HA and PGE 2 contents all increased significantly( P <0.01), but after moxibustion, the three contents decreased significantly( P <0.01). After moxibustion following the removal of the adrenal gland, HA content decreased significantly( P <0.05) but 5-HT and PGE 2 contents did not ( P >0.05). Conclusion Moxibustion treatment can markedly eliminate 5-HT, HA and PGE 2 in local inflammatory tissues so as to relieve local inflammatory reaction, edema and pains. The adrenal gland has an marked effect in moxibustion eliminating inflammatory media.
出处
《上海针灸杂志》
2002年第4期43-44,共2页
Shanghai Journal of Acupuncture and Moxibustion
