摘要
为探讨李仲愚杵针针刺镇痛效应的中枢作用机制，观测了杵针对正常大鼠及腹腔注射对氯苯丙氨酸（ Ｐ Ｃ Ｐ Ａ） 大鼠的不同脑区单胺类递质水平的影响，并与电针作比较。结果显示：杵针与电针一样，在刺激大鼠“足三里”穴区后，能明显提高间脑和端脑５羟色胺（５ Ｈ Ｔ） 与５羟醋酸吲哚（５ Ｈ Ｉ Ａ Ａ） 的含量（ Ｐ＜ ０ ．０１） ，同时也可使间脑去甲肾上腺素（ Ｎ Ｅ） 含量明显下降（ Ｐ＜ ０ ．０１） ，杵针对端脑的 Ｎ Ｅ 以及两脑区多巴胺（ Ｄ Ａ） 的影响未见明显影响。腹腔注射 Ｐ Ｃ Ｐ Ａ 后，大鼠脑内５ Ｈ Ｔ、５ Ｈ Ｉ Ａ Ａ 含量均明显下降（ Ｐ＜ ０ ．０１） ，杵针对其有上调趋势，且明显高于给药组与电针加给药组（ Ｐ＜ ０ ．０５ 或 Ｐ＜ ０ ．０１） ；杵针与电针均可使间脑、端脑 Ｎ Ｅ的水平升高至正常，而仅有杵针对间脑 Ｄ Ａ 的下降有恢复作用。提示：杵针镇痛效应的中枢机制与电针有一定相似性。
Objective:To shed light on the central nervous system mechanism of acupuncture analgesia effect of LI Zhongyu's clubbed needling.Method:Observed the stimulation effect of LI's clubbed needling to the contents of monoarminergic neurotransmitter in diencephalon and telencephalon of normal and received pare chlorophenylanime (PCPA) intapreitoneal injection rats.Result:To normal rats, stimulating the Foot Three Li (St.36) by LI's clubbed needling could increase the contents of 5 HT(5 hydroxytryptamine) and 5 HIAA in diencephalon and telencephalon, and could decreased the contents of NE(norepinephrine) in diencephalon. Meanwhile, the contents of DA(dopamine) in diencephalon and telencephalon and NE in telencephalon continued without appreciable change. After received PCPA intraperitioneal injection, the contents of 5 HI, 5 HIAA were decreased and stimulating by LI's clubbed needling could regain them to be close to normal status. The results were similar to the function of electroanalgesia. Conclusion:There was an analogy of analgecize effect between LI's clubbed needling and electro acupuncture.
出处
《成都中医药大学学报》
1999年第3期28-29,共2页
Journal of Chengdu University of Traditional Chinese Medicine
基金
国家重点科学技术项目
关键词
李仲愚
杵针
足三里
单胺类递质
神经递质
LI's clubbed needling
the Foot Three Li (St.36)
monoarminergic neurotransmitter
