摘要
目的:优化川佛手挥发油成分超临界CO_2萃取的提取工艺。方法:以挥发油得率为指标,分别考察萃取温度、萃取压力、CO_2流量、萃取时间、分离压力和分离温度等单因素对川佛手挥发油得率的影响。在此基础上,选取影响显著的萃取温度、萃取压力、CO_2流量和萃取时间4个因素,采用Box-Behnken响应面法优化超临界CO_2萃取工艺参数。结果:在萃取温度67℃、萃取压力57 MPa、CO_2流量22 L/h和萃取时间4 h时,川佛手挥发油超临界CO_2萃取得率最高,达到1.892%(n=3),与预测值(1.937%)的相对误差为2.32%。结论:优选的川佛手挥发油的超临界CO_2萃取工艺合理、可行。
OBJECTIVE： To optimize SFE-CO2 extraction technology of volatile oil from Citrisarcodactylis fructus. METHODS： Using the yield of volatile oil as index, the influences of extraction temperature, extraction pressure, CO2flow, extraction time, acquisition pressure and acquisition temperature on the yield of volatile oil were investigated. Moreover, 4 significant factors, such as extraction temperature, extraction pressure, CO2 flow and extraction time, were selected; the parameters of SFE-CO2 extraction technology were optimized by Box-Behnken design-response surface methodology. RESULTS： The results showed that the highest extraction rate could be obtained with extraction temperature at 67 ℃, extraction pressure at 57 MPa, CO2 flow at 22 L/ h and extraction time for 4 h. The highest extraction rate was 1,892% （n=3）, and the relative error between it and predicted value （1.937%） was 2.32%. CONCLUSIONS： Optimized SFE-CO2 extraction technology for volatile oil from C. fructus is reasonable and feasible.
出处
《中国药房》
CAS
北大核心
2016年第28期3973-3975,共3页
China Pharmacy
基金
四川省教育厅科研项目(No.16ZB0205)
