摘要
NMDA受体(N-Methyl-D-aspartate receptor,NMDAR)是兴奋性神经递质谷氨酸受体的一种亚型,参与体内神经发育、神经元的兴奋性、突触可塑性、神经元的死亡等多种不同的生理、病理过程。越来越多的研究显示NMDA不仅在神经系统发育、疼痛等发挥着重要的作用,且参与非神经细胞的增殖、分化及胃肠运动,本文旨在通过了解其与胃肠道肿瘤及功能性胃肠病的关系,研究NMDA受体在其中的作用,为临床从NMDA受体途径治疗消化道肿瘤及功能性胃肠病提供新思路,并对此作一概述。
N-Methyl-D-aspartate receptor （NMDAR） is a subtype of excitatory glutamate receptor, it mainly partici- pates in a variety of physiological and pathological processes such as the development of neural, the sensitization of cen- tral, and the death of neurons in vivo. Recently studies have shown that NMDA not only participates in the proliferation and differentiation of nerve cells, but also involves in the formation of the irritable gastric bowel movement. The purpose of this paper is to explore the role of NMDAR in it, and provide new train of thought, to treat digestive tract tumors and functional gastrointestinal through its relationship with the digestive system diseases.
出处
《胃肠病学和肝病学杂志》
CAS
2016年第9期1075-1078,共4页
Chinese Journal of Gastroenterology and Hepatology
基金
山东省自然科学基金(Y2008C141)
关键词
NMDA受体
胃肠道肿瘤
胃肠运动
N-Methyl-D-aspartate receptor
Gastrointestinal tumors
Gastrointestinal movement
