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NMDA受体与mGluR5之间的关系在疼痛研究中的新进展 被引量：6

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摘要 N-甲基-D-天门冬氨酸受体（N-Methyl-D-aspartate receptor,NMDA-R）和代谢型谷氨酸受体5（Metabotropic glutamate receptor 5,mGluR5）分别属于离子型兴奋性氨基酸受体及代谢型兴奋性氨基酸受体家族,两类兴奋性氨基酸受体是近年来在疼痛及其他精神相关疾患研究中最受关注的两类兴奋性氨基酸受体,基于对两类兴奋性氨基酸受体在吗啡耐受中的数年研究,作者对吗啡耐受中两类兴奋性氨基酸受体之间的联系产生极大兴趣,本文对疼痛的发生发展中两受体之间的交互作用（Cross-talk）作一综述.
作者 马霞青 许涛 江伟
机构地区 上海交通大学附属第六人民医院麻醉科
出处 《中国疼痛医学杂志》 CAS CSCD 北大核心 2014年第3期181-183,共3页 Chinese Journal of Pain Medicine
基金 国家自然科学基金青年基金(81200855) 上海市科委自然科学基金青年基金(12ZR1447300)
关键词 NMDA受体 MGLUR5 疼痛 交互作用
分类号 R402 [医药卫生—临床医学]
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参考文献20

  • 1郭张华,陈建平.NMDA受体在神经病理性疼痛中作用的研究进展[J].中国疼痛医学杂志,2013,19(3):173-176. 被引量：14
  • 2Qiu S,Li XY,Zhuo M.Post-translational modification of NMDA receptor GIuN2B subunit and its roles in chronic pain and memory.Semin Cell Dev Biol,2011,22:521-529.
  • 3虞雪融,黄宇光,罗爱伦.NMDA受体NR2B特异性拮抗剂Ifenprodil对CCI大鼠神经病理性疼痛的预防作用[J].中国疼痛医学杂志,2007,13(6):342-344. 被引量：4
  • 4Yan X,Jiang E,Gao M,et al.Endogenous activation of presynaptic NMDA receptors enhances glutamate release from the primary afferents in the spinal dorsal horn in a rat model of neuropathic pain.J Physiol,2013,591:2001-2019.
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  • 7Son MH,Kim JY,Lira EJ,et al.Synthesis and biological evaluation of 2-(arylethynyl)quinoline derivatives as mGluR5 antagonists for the treatment of neuropathic pain.Bioorg Med Chem Lett,2013,23:1472-1476.
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二级参考文献39

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  • 8Pisani A, Gubellini P, Bonsi P, et al. Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons. Neuroscience, 2001, 106: 579-587.
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共引文献16

同被引文献52

引证文献6

二级引证文献46

中国疼痛医学杂志
2014年 第3期

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