摘要
目的:研究阿奇霉素序贯疗法对小儿支原体肺炎患者炎性因子及体液免疫功能调节的影响。方法:选取2013年1月—2014年12月间诊治的小儿支原体肺炎患者100例作为研究对象;将其随机分为观察组和对照组,每组50例;对照组患者均给予阿奇霉素常规治疗,观察组患者均给予阿奇霉素序贯疗法治疗,治疗后检测两组患儿体内炎性因子(IL-10)、促炎因子(包括TNF-α、IFN-γ)以及体液免疫功能指标(包括免疫球蛋白Ig G、Ig A、Ig M和外周血中的补体C_3、C_4。结果:治疗前两组患儿血清中炎性因子均较高,经两组间比较其差异无统计学意义(P>0.05);治疗7和12 d时两组患儿血清中抗炎因子和促炎因子低于对照组(P<0.05);治疗前两组患儿外周血中Ig A水平处于较低水平,补体C_3、C_4以及Ig M、Ig G处于较高水平,经两组间比较其差异无统计学意义(P>0.05);治疗后两组患儿的Ig A水平上升,Ig M、Ig G下降,与治疗前比较其差异有统计学意义(P<0.05),且观察组患儿改善更加显著;观察组患儿补体C_3、C_4均显著下降;对照组患儿补体C3仍低于观察组(P<0.05),对照组患儿补体C_4与治疗前比较其差异无统计学意义(P>0.05)。结论:采用阿奇霉素序贯疗法治疗小儿支原体肺炎患儿,可显著改善其血清中炎性因子及体液免疫功能,其疗效优于阿奇霉素的常规治疗。
Objective：To observe the influence of Azithromycin sequential therapy on inflammatory cytokines and human immune function in children with Mvcoplasma pneumonia. Methods： A total of 100 cases with type 2 diabetes hildrcn with Mycoplasma pneumonia were randomly divided into control and experimental group from January 2013 to December 2014. The control group were given the traditional azithromycin therapy while the observation group were given the azithromycin sequential therapy. Serum anti-inflammatory and pro-inflammatory cytokines （1L-10, TNF-α, IFN-γ） as well as the content of IgA, IgG, IgM, C3 and C4 were detected before and after treatment respectively. Resuits： The changes of serum anti-inflammatory and pro-inflammatory cytokines at 4th and 10th day after the treatment in experimental group were all obviously bigger than those in control group, and the difference was statistically significant（P〈0.05）. After treatment, the levels of lgA and IgG in the control group were significantly higher those that of beforetreatment（P〈0.05）, the level of IgM was significantly lower（P〈0.05） and the levels of C3 and C4 were higher, but the differences were not significant （P〉0.05）. After treatment, significantly higher than those before treatment（P〈0.05）, and the levels of IgA and C, in the observation group were the level of lgM and IgG was significantly lower（P〈 0.05）, but there was no significant difference of the IgG and C4 levels after and before treatment（P〉0.05）. After the treatment, the level of IgA and C3 of the observation group was signifcantly higher than that of the control group（P〈 0.05）, and the level of IgG of the observation group was significantly lower than that of the control group（P〈0.05）, but the levels of lgM and C, had no significant difference between the two groups（P〉0.05）. Conclusion： Azithromycinhas in- fluence on the anti-inflammatory and pro-inflammatory cytokines and immunological function in children with Mycoplasma pneumonia, and had obvious improving effect on their inflammatory and immune state.
出处
《抗感染药学》
2016年第4期850-853,共4页
Anti-infection Pharmacy
关键词
阿奇霉素
支原体肺炎
炎性因子
体液免疫
azithromycin
Mycoplasma pneumonia
inflammatory factor
humoral immunity
