摘要
目的探讨罗库溴铵在布依族与汉族患者是否存在时效差异.方法择期全麻妇科腔镜手术40例,随机分为两组：H组（汉族组,n=20）;B 组（布依族组,n=20）,入室开放左上肢静脉,常规监测后,静脉注射咪达唑仑0.1mg/kg、芬太尼 4μg/kg,靶控输注丙泊酚血浆靶浓度 2~3μg/ml, BIS 值稳定在 60后,TOF-Watch SX肌松监测仪定标,采用单刺激模式（0.1Hz,0.2ms）,刺激颤搐高度在100%时静脉注射罗库溴铵0.6mg/kg,待刺激颤搐高度降至10%后行气管插管连接麻醉机,行机械正压通气.依次记录罗库溴铵起效时间（T1）、无反应期（T2）、临床维持时间（T3）、75%恢复时间（T4）、恢复指数（T5）. 结果B组罗库溴铵起效时间（T1）明显长于H组 （155.00±51.08s vs 124.50±33.60s）,差异具有统计学意义（P 〈0.05）;两组无反应期（T2）、临床维持时间（T3）、75%恢复时间（T4）、恢复指数（T5）比较,差异无统计学意义（P 〉 0.05）.结论布依族患者罗库溴铵起效较汉族慢.
ObjectiveTo compare the time-course of action of rocuronium between Buyi and Han ethnic groups.MethodsFifty femals patients undergoing general anesthesia were divided into two goups：group H （Han ethnic group,n=20）;group B （Buyi ethnic group,n=20）.Anesthesia was induced with midazolam 0.1mg/kg,fentanyl 4μg/kg,TCI of propofol （target plasma concerntration 2~3μg/ml）,after BIS maintained 60,calibrated the TOF Watch-SX, stabilized the stimulate twitch height at 100%.Tracheal intubation was facilitated with rocuronium 0.6mg/kg.Selected IPPV model. Neuromuscular block was assessed with acceleromydgraph F （TOF Watch-SX）using single stimulation （0.1Hz,0.2ms） of the ulna nerve.Recorded the onset time （T1）,nonresponse time（T2）,clinical duration time（T3）,75% recovery time（T4） and recovery index （T5）.ResultThe onset time（T1）in group B was 155.00±51.08s and 124.5±33.60s in group H,it is longer in Buyi ethnic group than Han ethnic group.There were not significant differences in nonresponse time（T2）,clinical duration time（T3）,75% recovery time（T4） and recovery index（T5） between two ethnic groups.ConclusionCompared to Han ethnic group,the onset time in Buyi ethnic group is longer.
出处
《湖南中医药大学学报》
CAS
2016年第A01期203-203,共1页
Journal of Hunan University of Chinese Medicine
基金
贵州省优秀省长基金项目项目编号：黔省专20100152号
关键词
布依族
汉族
罗库溴铵
神经肌肉阻滞
Buyi ethnic group
Han ethnic group
rocuronium
neuromuscular blockadex
