摘要
目的比较维族和汉族患者罗库溴铵的肌松时效。方法择期拟在全麻下行甲状腺手术的维吾尔族患者（W组）和汉族患者（H组）各15例，ASAⅠ或Ⅱ级，性别不限，年龄20-55岁，体重45—73kg。静脉注射眯达唑仑、异丙酚、芬太尼和琥珀胆碱行麻醉诱导气管插管后，静脉注射罗库溴铵0．6mg／kg，采用加速度仪单个刺激模式监测肌松起效时间、无反应期、临床维持时间、75％恢复时间和恢复指数。结果两组肌松起效时间比较差异无统计学意义（P〉0．05）；与H组比较，W组无反应期、临床维持时间、75％恢复时间及恢复指数均明显缩短（P〈0．05）。结论维吾尔族与汉族患者罗库溴铵的肌松时效存在明显差别，临床上用量需要考虑民族差异的影响。
Objective To compare the time-course of relaxant effect of rocuronium between patients of Uygnr and Han nationalities. Methods Thirty ASA Ⅰ or Ⅱ patients （15 Uygur nationality, 15 Hart nationality） of both sexes, aged 20-55 yr weighing 45-73 kg were divided into 2 groups （n = 15 each）： group U Uygur nationality and group H Han nationality. Anesthesia was induced with midazolam, propofol, fentanyl and suxarnethonium chloride. Tracheal intubation was performed and the patients were mechanically ventilated＇. Rocuronium 0.6 mg/kg was then given iv. Neuromuscular function was monitored with acceleromyograph using single stimulation of the ulna nerve. The onset time （time from injection of rocurnnium to maximal paralysis）, nouresponse time （duration of maximal twitch depression）, clinical duration （time required for the twitch to return to 25% of control height after injection of initial dose）, 75% recovery time （time for twitch to return to 75% of control height after injection of initial dose） and recovery index （time for twitch height to return from 25% to 75% of control height） were recorded. Results There was no significant difference in the onset time between the two nationalities. The time of nonresponse period, clinical duration and 75 % recovery time were significantly shorter in Uygur patients than in Han patients. Recovery index was significantly shorter in Uygur patients. Conclusion There is a significant difference in the time-course of muscle relaxant effect of recuronium between Uygur and Han nationalities. The influence of nationality on recommended dosage of rocuronium should be considered.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
2010年第3期266-268,共3页
Chinese Journal of Anesthesiology
关键词
雄甾烷醇类
维吾尔族
汉族
神经肌肉阻滞
Androstanols
Uygnr nationality
Han nationality
Neuromuscular blockade
