摘要
目的：探讨我院药品不良反应（ADR）发生的临床特点、规律,为临床合理、安全用药提供参考。方法：对广东省ADR监测中心收录的我院2014年1月-2015年6月的ADR报告进行整理、统计与分析。结果：433例发生ADR的患者中,男性185例（42.73%）,女性248例（57.27%）,男女比例为1∶1.34。中青年（20~59岁）患者ADR发生率较高（71.59%）,且男性明显少于女性（1∶1.37）。ADR给药途径以静脉滴注（48.04%）和口服给药（41.57%）为主。抗感染药物引发ADR的例数最多（167例,38.57%）,其中以头孢菌素类为主（64.07%）。ADR累及器官/系统以消化系统损害（262例次,36.19%）和皮肤及其附件损害（237例次,32.73%）为主。严重的ADR主要涉及抗感染药物和抗肿瘤药物。结论：临床医务人员应加强头孢菌素类抗菌药物和抗肿瘤药物的ADR监测,谨慎选择给药途径。
OBJECTIVE：To investigate the clinical characteristics and regularity of adverse drug reaction（ADR）,and to provide reference for rational and safe drug use in the clinic. METHODS：ADR reports collected from our hospital by Guangdong ADR Monitoring Center during Jan. 2014 to June. 2015 were summarized and analyzed statistically. RESULTS：Of 433 ADR cases,there were 185 male cases（42.73%）and 248 female cases（57.27%）,with ratio of 1∶1.34. The incidence of ADR was in high level（71.59%）in young and middle-aged patients（20-59 year-old）;that of male was significantly lower than that of female（1∶1.37）.ADR cases caused by intravenous drip（48.04%）and oral administration（41.57%）were most common. The most ADR cases were related with anti-infective drugs（167 cases,38.57%）,mainly were related with cephalosporins（64.07%）. Organs/systems involved in ADR were main the damages of gastrointestinal system（262 cases,36.19%） and the lesion of skin and appendants（237 cases,32.73%）. The serious ADR was mainly induced by anti-infective and anti-tumor drugs. CONCLUSIONS：Clinical medical personnel should strengthen the ADR monitoring of cephalosporin antibiotics and anti-tumor drug,and select route of administration carefully.
出处
《中国药房》
CAS
北大核心
2016年第26期3640-3643,共4页
China Pharmacy
关键词
药品不良反应
分析
合理用药
Adverse drug reaction
Analysis
Rational drug use
