摘要
目的观察剖宫产产褥感染产妇细胞因子与红细胞免疫状态的变化,以了解产褥感染产妇机体免疫与炎性状态的调节情况,为该类感染患者的治疗与诊断提供依据。方法选取2013年7月-2015年10月于医院进行诊治61例剖宫产产褥感染产妇为观察组,同时期61例未发生产褥感染的剖宫产产妇为对照组,比较两组细胞因子与红细胞免疫指标,数据采用SPSS 17.0软件进行统计分析。结果观察组血清白细胞介素(IL)包括IL-1β、IL-6、IL-8及IL-10水平分别为(3.24±0.40)(11.48±1.45)(13.43±1.60)及(25.51±2.50)pg/ml,均高于对照组,同时其他细胞因子及红细胞免疫指标均低于对照组,且观察组中不同白细胞水平患者的细胞因子与红细胞免疫指标间差异均有统计学意义(P<0.05)。结论剖宫产产褥感染产妇细胞因子与红细胞免疫状态处于相对较差的状态,且感染严重的患者其状态更差,应给予充分监测与干预。
OBJECTIVE To observe the changes of cytokines and erythrocyte immune state of delivery women with cesarean section and puerperal infection,in order to understand the regulation situation of immune and inflammatory state of delivery women with puerperal infection,and provide evidences for the diagnosis and treatment of the patients with infection.METHODS A total of 61 cases of delivery women with cesarean section and puerperal infection in our hospital from Jul.2013 to Oct.2015 were selected as observation group,another 61 cases of delivery women with cesarean section and without puerperal infection at the same time were selected as control group,then the cytokines and erythrocyte immune indexes of the two groups were compareds.RESULTS The serum interleukins IL-1β,IL-6,IL-8and IL-10 of observation group were（3.24±0.40）pg/ml,（11.48±1.45）pg/ml,（13.43±1.60）pg/ml and（25.51±2.50）pg/ml,respectively,which were all higher than those of control group,other cytokines and erythrocyte immune indexes were all lower than those of control group,and the cytokines and erythrocyte immune indexes of observation group with different white blood cell levels had significant differences（P〈0.05）.CONCLUSIONThe cytokines and erythrocyte immune state of delivery women with cesarean section and puerperal infection show relatively worse state,and the state is worse when the infection is more serious,so they should be paid enough monitoring and intervention.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第15期3543-3545,共3页
Chinese Journal of Nosocomiology
基金
河南省卫计委基金资助项目(201349896F)
关键词
剖宫产
产褥感染
细胞因子
红细胞免疫状态
Cesarean section
Puerperal infection
Cytokines
Erythrocyte immune state
