摘要
目的探讨膀胱镜检查后患者尿路感染的病原菌分布及其耐药性的特异性,以指导临床抗菌药物的使用。方法选取2012年-2015年医院接受膀胱镜检查后引发尿路感染的患者142例列为院内组,另选取同期门诊收治尿路感染患者218例列为院外组,取患者中段尿使用全自动细菌生化分析仪进行细菌测定及药敏试验,采用WHONET 5.4微生物统计软件分析病原菌的分布及耐药性。结果院内组患者142份尿液培养标本共分离病原菌142株,以革兰阴性菌为主,共87例,占61.27%;院外组218份标本共分离病原菌218株,以革兰阴性菌为主,共140例,占64.22%;院内组革兰阴性菌对氨苄西林的耐药率最高,为66.67%;院外组革兰阴性菌对氨苄西林的耐药率最高,为61.42%。结论膀胱镜检查后尿路感染的主要致病菌为大肠埃希菌及肠球菌属,首选治疗药物喹诺酮类耐药率较高,对与膀胱镜检查后尿路感染患者的抗菌药物使用应提高针对性。
OBJECTIVE To investigate the distribution and drug resistance of pathogens in patients with urinary tract infections（UTI）after cystoscopy,so as to guide clinical use of antibacterials drugs.METHODS A total of142 patients with UTI after cystoscopy in hospital from 2012 to 2015were selected as hospital group,and 218 cases with UTI out of hospital were selected as out-hospital group at the same period.Pathogens and drug susceptibility of midstream urine were tested using automatic bacteria biochemical analyzer,and distribution and drug resistance of pathogens were analyzed by WHONET 5.4microbial statistical software.RESULTS Totally 142 cases of bacteria were isolated in hospital group,with the majority of 87 strains of gram-negative bacteria,accounting for 61.27%;and 218 cases of bacteria were isolated in out-hospital group,with the majority of 140 strains of gram-negative bacteria,accounting for 64.22%.The highest drug resistance of gram-negative bacteria of hospital group and out-hospital group were both to ampicillin,with the resistant rates of 66.67% and 61.42%.CONCLUSIONThe main pathogens in patients with urinary tract infection after cystoscopy are Escherichia coli and Enterococcus,and the resistance to quinolones is high.It should be pay more attention for the use of antibacterials drugs in patients with urinary tract infection after cystoscopy.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第15期3489-3491,共3页
Chinese Journal of Nosocomiology
基金
青海省基本科技计划基金资助项目(2014S70)
关键词
膀胱镜
尿路感染
病原菌
耐药性
Cystoscopy
Urinary tract infections
pathogens
drug resistance
