摘要
目的分析前白蛋白对慢性阻塞性肺病(COPD)的临床诊断价值,并分析患者感染病原菌对前白蛋白水平的影响,为临床诊断与治疗提供参考依据。方法选取医院2013年4月-2015年2月170例COPD合并感染患者为感染组,分析患者血清中前白蛋白水平变化及患者感染病原菌的分布,同期选取健康体检者120名为对照组,比较两组患者临床指标,数据采用SPSS 19.0软件进行统计分析。结果 170例感染患者送检标本共分离出178株病原菌,以革兰阴性菌为主,共94株占52.8%;感染组患者血清前白蛋白水平明显降低,而白细胞介素-2、白细胞介素-6和白细胞介素-10水平明显升高,且与对照组相比,差异均有统计学意义(P<0.05)。结论前白蛋白对临床诊断COPD具有重要的参考价值,且感染后患者血清前白蛋白水平明显降低。
OBJECTIVE To explore the diagnosis value analysis of pre-albumin（PA）on COPD and analyze the effect of pathogens causing infections on PA,so as to provide reference for clinical diagnosis and treatment.METHODS A total of 170 cases of patients with COPD combined infection in our hospital from Apr.2013 to Feb.2015 were enrolled as infection group.The level change of PA in serum and pathogens distribution were under analysis,and at the same time,120 cases of healthy subjects were chosen as control group.The clinical indexes from two groups were compared and SPSS 19.0was used for statistic analysis for data.RESULTS A total of 178 strains of pathogens were isolated from the specimen from the 170 cases of patients,mainly gram-negative bacteria,totally 94 strains,accounting for 52.8%.The PA in serum decreased significantly in infection group,but the interleukin-2（IL2）,IL6 and IL10increased greatly,and the difference was significant compared with control group（P〈0.05）.CONCLUSIONPA can be taken as a valuable indicator for the diagnosis of CODP and the PA is decreased significantly after infection.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第15期3387-3388,3397,共3页
Chinese Journal of Nosocomiology
基金
重庆市卫生局基金资助项目(209-4-117)
