摘要
1例72岁男性抑郁症患者应用奥氮平（7.5 mg/ d）合并氟伏沙明（125 mg/ d）口服治疗2个月后出现发热、意识障碍、肌强直、多汗、心动过速，WBC 12.3×109/ L，血清 CK 737 U/ L。停用所有口服药物，给予持续吸氧、心电监护、保持呼吸道通畅、物理降温、维持水电解质及酸碱平衡、控制感染等处置，并静脉滴注氯硝西泮1 mg/ d，口服多巴胺受体激动剂吡贝地尔100 mg/ d。3 d 后患者体温恢复正常，意识转清，5 d 后肌张力及血常规各项指标和血清 CK 恢复正常。
A 72-year-old man with depression received oral olanzapine 7. 5 mg/ d and fluvoxamine 125 mg/ d. Two months after the drug administration,the patient developed fever,consciousness,rigidity, sweating,and tachycardia. Blood tests showed that the white blood cell count was 12. 3 × 109 / L and creatine kinase（ CK ） level was 737 U/ L. All drugs were stopped and continuous oxygen inhalation, electrocardiographic monitoring and measures for keeping the respiratory tract unobstructed were given. Ice pillows and ice packs were used to lower his temperature. Treatments such as fluid infusion,correction of water-electrolyte balance,infection prevention,intravenous infusion of clonazepam 1 mg once daily,and oral dopamine receptor agonist piribedil 100 mg once daily were also given. Three days later,his temperature returned to normal and his consciousness turned clear. Five days later,his muscle tension,routine blood test,and CK level returned to normal.
出处
《药物不良反应杂志》
CSCD
2016年第3期230-232,共3页
Adverse Drug Reactions Journal
关键词
抗精神病药
氟伏沙明
恶性综合征
Antipsychotic agents
Fluvoxamine
Neuroleptic malignant syndrome
