摘要
目的 :通过检测鼻息肉组织中细胞间粘附分子 (ICAM- 1) ,血管细胞粘附分子 (VCAM- 1)及肿瘤坏死因子(TNF-α)的表达 ,以了解三者与嗜酸性粒细胞浸润的关系 ,探讨粘附分子与 TNF-α的相关性。方法 :分别以 ICAM- 1、VCAM- 1及 TNF-α的单克隆抗体对 4 2例鼻息肉组织 (鼻息肉组 )和 16例鼻甲粘膜 (对照组 )进行免疫组织化学染色 ,光镜观察。结果 :ICAM- 1、VCAM- 1及 TNF-α在鼻息肉组织中的表达均明显高于对照组 (P <0 .0 1) ,ICAM- 1、VCAM- 1与 TNF-α的表达呈正相关 (r1 =0 .5 2 ,p1 <0 .0 1;r2 =0 .6 8,p2 <0 .0 1)。鼻息肉中两种细胞粘附分子与嗜酸性粒细胞浸润程度一致。结论 :1嗜酸性粒细胞在鼻息肉的发生发展中发挥重要作用 ;2而 TNF-α通过上调鼻息肉组织内皮细胞ICAM- 1及 VCAM- 1的表达 ,从而促进嗜酸性粒细胞与内皮细胞的粘附 ,穿内皮迁移、聚集于组织局部 ,引起鼻息肉形成。
Objective:To study the expressions and significance of ICAM\|1 (intercellular adhesion molecular\|1),VCAM\|1(vascular adhesion molecular\|1) and TNF α(tumor necrosis factor α)in nasal polyps.Methods:The expression of ICAM\|1,VCAM\|1 and TNF α was determined by immunohistochemical technique in tissue of nasal polyps(42 patients),in inferior turbinates(16 normal subjects,control group).Results:The expressions of ICAM 1,VCAM 1 and TNF α were stranger in nasal polyps than that in control group (P<0.05).There were positive relationship between the expression of TNF α and that of ICAM 1 and VCAM 1(r 1=0.52,p 1<0.01;r 2=0.68,p 2<0.01).Conclusion:Result suggested that the eosinophil infiltration should be a prominent role in the development and recurrence of nasal polyps.TNF α may up regulate the expression of ICAM 1 and VCAM 1 in vascular endothelium and prompt adhesion and migration of eosinophil.It showed that the ICAM 1,VCAM 1 and TNF α should be important role in the pathogens of nasal polyps.
出处
《耳鼻咽喉（头颈外科）》
2002年第4期243-246,W002,共5页
Chinese Arch Otolaryngology-Head Neck Surg
