摘要
目的了解急诊患者血清中抗核抗体(ANA)的检出率,探讨自身抗体在急诊患者中的诊断价值。方法回顾性分析2013年5月至2015年7月本院急诊患者自身抗体检出率与首诊症状的相关关系。结果 616例急诊患者ANA阳性率为10.9%(67/616),其中诊断为系统性红斑狼疮的ANA阳性率为100%(3/3),出现肢体疼痛、浮肿和肌无力,发热咳嗽,胸闷和呼吸困难等症状患者的ANA阳性率较高,分别是36.7%(11/30)、13.0%(15/115)、22.9%(8/35)。在67例ANA阳性患者中,滴度大于等于1∶320的患者占68.7%(46/67)。抗核抗体谱阳性患者114例,占18.5%(114/616),其中以抗Ro-52、抗SS-A、抗HI、抗M2抗体的阳性率较高,分别为8.1%(50/616)、6.8%(42/616)、3.1%(19/616)和2.8%(17/616)。结论对急诊就诊者出现关节疼痛、浮肿,发热、呼吸困难等症状的患者应提高警惕,注意多种自身抗体的联合检测,提高自身免疫性疾病的诊断率,以防漏诊。
Objective To explore the positive rate of antinuclear antibodies（ANA）,and to discuss the diagnostic value of it in emergency patients′autoimmune disease.Methods A total of 616 emergency patients admitted to the First Affiliated Hospital of Kunming Medical University from May 2013 to July 2015 were selected in a retrospective analysis;ANA were detected and the relationship between ANA and the primary clinical symptoms were analyzed.Results The positive rate of the ANA in patients was10.9%（67/616）,which in Systemic Lupus Erythematosus（SLE）was 100%（3/3）;and patients with the special clinical symptoms had a higher positive rate,such as muscle pain,swelling with weakness was 36.7%（11/30）,fever and cough was 13.0%（15/115）and chest tightness with shortness of breath was 22.9%（8/35）.Patients with the titers of ANA highter than 1∶320were 68.7%（46/67）.Patients with the positive ANA spectrum（114cases）accounted for 18.5%（114/616）,among whom with Ro-52,SS-A,HI and AMA-M2 accounted much higher,the rates were 8.1%（50/616）,6.8%（42/616）,3.1%（19/616）and 2.8%（17/616）.Conclusion The emergency patients with symptoms including muscle pain and swelling,fever and breathing difficulties should be vigilant.So it is necessary to diagnose the autoimmune diseases by combined detecting a variety of antibodies so as to reduce the rate of missed diagnosis.
出处
《国际检验医学杂志》
CAS
2016年第10期1355-1357,共3页
International Journal of Laboratory Medicine
关键词
急诊
抗核抗体
自身免疫性疾病
emergency
antinuclear antibodies
autoimmune disease
