摘要
脊髓损伤（spinal cord injury,SCI）是一种严重的神经系统功能障碍性疾病,能导致不同程度的感觉和运动功能障碍,主要包括原发性损伤和继发性损伤。原发性损伤是指在外力的直接作用下导致脊髓组织机械性的破坏,其伤害通常是不可逆的;继发性损伤是指在原发性损伤的基础上出现病理生理方面的改变从而造成损伤区域渐进性破坏,临床上主要针对继发性损伤采取相关治疗措施。
Spinal cord injury（ SCI） is a devastating disease of the central nervous system. It elicits permanent neurological dysfunction. The neuroinflammation is a key point within the secondary damage in the locoal area of SCI. Peroxisome proliferator-activated receptors（ PPARs）,a group of ligand-activated transcription factors,play a critical role in the degenerative diseases in the central nervous system and acute traumatic injury because of their biological effects of antiinflammation and neuroprotection when they are activated. This article reviews the signal transduction pathway mediated by PPARs and the progress of PPARs in the repair of SCI.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2016年第5期956-960,共5页
Chinese Journal of Pathophysiology
基金
浙江省自然科学基金资助项目(No.LY15H170001)
关键词
过氧化物酶体增殖物激活受体
脊髓损伤
信号通路
Peroxisome proliferator-activated receptors
Spinal cord injury
Signaling pathway
