摘要
以ABC—ELISA法检测了220例成年人重症肌无力病者血清中IgG-Ach-Rab和IgG PrMab。根据检测抗体的阳性发现和临床特点,将重症肌无力分为四组:(Ⅰ)IgG-AchRab阳性,(Ⅱ)IgG-PrMab阳性,(Ⅲ)IgG-AchRab和IsG-PrMab均阳性,(Ⅳ)IgG-AchRab和IgG-PrMab均在正常范围。分析各组临床特点和对激素治疗反应认为:(1)型病者病程较长,激素治疗即时效果好,但易复发;(2)型病程短,激素治疗效果好,而且无复发;(3)型病程也短,激素治疗和胸腺切除效果较差,合并其它自身免疫病的机会高;(4)型激素治疗反应差,胸腺切除治疗效果好。
Based on the clinical pictures and antibodies to acetylcholine receptor (Ac-hR) and presynaptic membrane (PrM) in sera from 220 cases of adult myast-henia gravis (MG),we divided them into four groups: (1) Positive IgG-AchR,(2) positive IgG-PrM,(3) both IgG-AchR and IgG-PrM positive,(4) both IgG-AchR and IgG-PrM negative.It was shown that the first group of MG had longer duration,good response to steroid but was more recurent,the second group had shorter duration,excellent response to steroid and no recurence,the third group had shorter duration,and was often complicated with other autoimmune disease or thyoma,and had poor results of thymectomy and steroid therapy,the fourth group had poor response to steroid and excellent one to thymectomy.It was suggested that thymoma and other autoimmune diseases should be excluded in MG patients with the antibodies positive,particuraly in those with antibodies both to AchR and prM.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
1991年第2期65-68,共4页
Chinese Journal of Nervous and Mental Diseases
