摘要
目的探讨血清R yanod ine受体抗体(R yR-A b)对胸腺瘤并重症肌无力(M G)的诊断价值。方法选择经病理检查证实为胸腺病变并M G的患者35例,其中胸腺瘤并M G患者(M GT组)17例、胸腺增生并M G患者(M GH组)12例、胸腺萎缩并M G患者(M GA组)6例,同时选择胸腺正常的M G患者(NTM G组)27例,健康对照者(NC组)50例;采用EL ISA法检测其血清R yR-A b。结果M GT组血清R yR-A b阳性率为76.5%,M GH组为8.3%,M GA组为16.6%,NTM G组为0,NC组为0。结论M GT患者血清R yR-A b阳性率较高,检测血清R yR-A b有助于M GT的诊断。
Objective： To investigate the role of Ryanodine receptor antibodies （RyR-Ab） in diagnosing thymoma with myasthenia gravis （MG）. Methods： 35 cases of thymic disease with MG including 17 cases of thymoma with MG（MGT group）, 12 cases of thymic hyperplasia with MG （MGH group）, 6 cases of thymic atrophy with MG （MGA group）, and 27 cases of normal thymus with MG （NTMG group）, 50 cases of normal controls （NC group）.The RyR-Ab was tested in sera of these patients with ELISA. Results： The positive percentage of RyR-Ab was 76.5%（13/17）in MGT group,8.3% in MGH group, 16.6% in MGA group,0 in NTMG group,0 in NC group. Conclusion：The RyR-Ab is mostly found in patients with MGT, RyR-Ab testing is useful in diagnosing MGT.
出处
《山东医药》
CAS
北大核心
2005年第24期17-18,共2页
Shandong Medical Journal
基金
山东省自然科学基金资助项目(200213YC)
