摘要
基于真实世界分析当归-川芎配伍在中医临床处方中的应用情况,为解释中药药对内在配伍规律和临床用药所治疾病科属之间的关系提供参考。从某大型三甲中医医院自2014年4月1日至2014年6月30日期间医生开具的所有住院处方中,选择同一处方药物组成同时含有"当归"、"川芎"2味中药的所有住院处方,共计8 792首方,建立数据库,统计分析当归-川芎配比、剂量、疾病科属分布等情况。结果表明,当归、川芎以1∶1在临床中使用的频次最多,占42.4%,使用剂量以当归、川芎均为15 g为主,所治疾病科属主要为脑病科和肺病科;当归-川芎>1∶1占处方总数的33.3%,其中配比3∶2出现的频次最高,使用剂量以当归15 g、川芎10 g为主,所治疾病科属主要为脑病科;当归-川芎>1∶1占处方总数的24.3%,其中配比2∶3出现的频次最高,使用剂量以当归10 g、川芎15 g为主,所治疾病科属主要为脑病科。采用统计分析方法研究中药药对在临床实际应用处方中的配伍及应用特征,能有效发现中医临床治疗疾病的用药规律,为临床遣方用药提供理论依据,为药对的现代研究提供科学指引和可靠的数据基础。
To analyze the clinical application characteristics of Danggui-Chuanxiong（ DG-CX） herb pair in Chinese medicines on basis of real-world,and provide reference for explaining the inherent compatibility regularity and the relationship between clinical applications and disease species. From April 1,2014 to June 30,2014,a total of 8 792 prescriptions with both ＂ DG＂ and ＂CX＂ in a large third-grade class-A traditional Chinese medicine（ TCM） hospital were selected to establish the database for analyzing the ratio,dosage,and corresponding disease species of DG-CX herb pair. The results showed that, ＂ DG-CX ＂ with ratio ＂ 1 ∶ 1 ＂ had the highest frequency in clinical application（ 42. 4 %）; the dosage was mainly of 15 g for both DG and CX; the disease species were mainly of encephalopathy and pulmonary diseases. ＂ DG-CX＂ herb pairs with a ratio greater than ＂ 1 ∶ 1 ＂ accounted for 33. 3 % of all the prescriptions,and the ratio ＂ 3 ∶ 2 ＂ appeared to be most frequent among them; the dosage was mainly of 15 g for DG and and 10 g for CX; the disease species were mainly of encephalopathy diseases. ＂ DG-CX＂ herb pairs with a ratio less than ＂ 1 ∶ 1 ＂ accounted for 24. 3 % of all the prescriptions,and the ratio ＂ 2 ∶ 3 ＂ appeared to be most frequent among them; the dosage was mainly of 10 g for DG and 15 g for CX; the disease species were mainly of encephalopathy diseases. Statistical method was applied to study the compatibility and application characteristics of Chinese herb pairs in clinical prescriptions,effectively discover the medication regularity,provide theoretical basis for clinical herbal prescriptions and provide scientific guidance and reliable data for modern research of Chinese herb pairs.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2016年第7期1338-1341,共4页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(U1504827)
关键词
当归
川芎
药对
真实世界
数据分析
Danggui
Chuanxiong
herb pair
real-world
data analysis
