摘要
目的:了解综合医院医院感染的病原菌分布及其耐药性,为临床合理选择抗菌药物提供参考。方法:选取深圳市宝安区石岩人民医院(以下简称"我院")2014年收治的12 500例患者作为研究对象,采集感染标本4 152份,进行病原学培养,根据病原学结果统计病原菌的分布及其对抗菌药物的敏感性。结果:12 500例患者中,出现感染者4 000例(占32.00%),主要分布于重症监护病房、呼吸科、神经内科、儿科,分别占18.20%(728/4 000)、16.10%(645/4 000)、11.10%(442/4 000)、12.10%(484/4 000)。培养、分离出的病原菌共1 184株,其中,革兰阳性菌225株(占19.00%),主要为链球菌,葡萄球菌;革兰阴性菌696株(占58.78%),主要为大肠埃希菌、鲍曼不动杆菌;真菌263株(占22.21%)。所分离出的金黄色葡萄球菌对青霉素、红霉素、克林霉素等的耐药率均高于80.00%;革兰阴性菌中也存在多种耐药菌,尤以鲍曼不动杆菌最为常见。结论:我院新近发生院内感染的常见病原菌以革兰阴性菌为主,且存在严重的耐药问题,提醒临床应加强抗菌药物的合理应用。
OBJECTIVE：To investigate the distribution and antibacterial resistance of nosocomial infection pathogens in general hospital,so as to provide reference for the rational selection of antibiotics in clinic.METHODS：12 500 patients admitted into Shenzhen Bao‘an District Shiyan People＇s Hospital（hereinafter referred to as ＂our hospital＂） were selected,4 152 infectious samples were collected to conducted the etiology culture,the distribution of pathogens and the sensibility to antibiotics were statistically analyzed through the results of pathogeny.RESULTS：Among 12 500 patients,4 000 cases were infectious specimens（32.00%）,mainly distributed in the department of ICU,respiratory,neurology,pediatrics,respectively accounting for 18.20%（728 /4 000）,16.10%（645 /4 000）,11.10%（442 /4 000） and 12.10%（484 /4 000）.1 184 pathogen strains were cultured and isolated,among which,225 strains were gram-positive bacterium（19.00%）,mainly for streptococcus,staphylococcus aureus;696 strains were gram-negative bacteria（58.87%）,mainly for escherichia coli and acinetobacter baumannii;263 strains were fungus（22.21%）.The antibacterial resistance rate of staphylococcus aureus isolated from parents to penicillin,erythromycin,clindamycin resistance was higher than 80.00%.And there were a variety of drug-resistance bacteria in gram-negative bacteria,especially acinetobacter baumannii was the commonly used one.CONCLUSIONS：Most pathogens isolated from patients with nosocomial infection are gram-positive bacteria,and the antibacterial resistance is severe,thus it is necessary to remind the clinic to strengthen the rational application of antibiotics.
出处
《中国医院用药评价与分析》
2016年第4期535-537,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
深圳市宝安区科技计划资助课题(No.2015280)
关键词
医院感染
病原菌
耐药性
分析
Nosocomial infection
Pathogens
Antibacterial resistance
Analysis
