摘要
目的:观察乌司他丁对急性心肌梗死患者溶栓后血浆N末端脑钠肽前体(NT-proBNP)水平的影响。方法:纳入2014年6月—2016年3月收治的急性心肌梗死患者130例,根据电脑随机平均分配的原则将其分为对照组和观察组各65例。对照组患者接受常规治疗,观察组患者在常规治疗的基础上,再给予乌司他丁进行治疗。2组患者均进行为期3 d的治疗,比较2组患者溶栓当日与3 d后的左心室射血分数,观察并比较2组患者血浆NT-proBNP质量浓度的变化。结果:溶栓前,2组患者血浆NT-proBNP质量浓度的差异无统计学意义(P>0.05);溶栓后30 min、2、6、24 h,观察组患者血浆NT-proBNP质量浓度均明显低于对照组,差异有统计学意义(P<0.05)。溶栓当日和溶栓3 d后,观察组患者左心室射血分数均明显高于对照组,差异有统计学意义(P<0.05)。结论:应用乌司他丁对急性心肌梗死患者进行治疗,可显著改善患者的血浆NT-proBNP水平,提高左心室射血分数。
OBJECTIVE：To observe the effects of ulinastatin on plasma NT-proBNP after thrombolysis in patients with myocardial infarction.METHODS：130 patients with acute myocardial infarction admitted from Jun.2014 to Mar.2016 were selected to be divided into control group and observation group,according to the principle of equal distribution of computer.The control group received conventional therapy,while the observation group were treated with ulinastatin based on the control group.Two group of patients were on treatment of 3 d,the left ventricular ejection fraction were compared between two groups in the day of thrombolysis and after 3 d of thrombolysis;the changes of mass concentration of NT-proBNP were observed and compared between two groups.RESULTS：Before thrombolysis,there was no statistically significance in mass concentration of NT-proBNP between two group of patients（P〉 0.05）.After thrombolysis of 30 min,2 h,6 h and 24 h,the mass concentration of plasma NT-proBNP in observation group was significantly higher than that of control group,with statistically significance（P〈 0.05）.In the day of of thrombolysis and after 3d of thrombolysis,the left ventricular ejection fraction were higher than that of control group,with statistically significance（P〈 0.05）.CONCLUSIONS：Ulinastatin in treatment of acute myocardial infarction can significantly improve the patient＇s plasma NT-proBNP and improve left ventricular ejection fraction.
出处
《中国医院用药评价与分析》
2016年第4期491-493,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
