摘要
目的探讨转录因子GATA-3在乳腺癌组织中的表达及临床价值。方法选取2013年5月1日至2015年11月1日在该院就诊的382例乳腺癌患者进行研究,并经由随机分类的方式分为乳腺恶性肿瘤组织组(254例)、乳腺良性肿瘤组织组(58例)及乳腺癌旁组织组(70例)。同时对比观察各组中GATA-3的表达,分析GATA-3表达和乳腺癌形态学分类的关系及GATA-3表达与乳腺癌临床病理特征的相关性。结果乳腺恶性肿瘤组织中的GATA-3表达阳性率为79.53%(202/254)。三阴型乳腺癌细胞中的GATA-3阳性率低于腺腔A型、腺腔B型及HER-2过表达型,差异均有统计学意义(P<0.05)。GATA-3在浸润性导管癌组织、浸润性小叶癌组织及神经内分泌癌组织中表达,而在弥漫性大B细胞淋巴瘤和恶性梭形细胞肿瘤组织中不表达。结论在乳腺癌细胞中乳腺肿瘤的病理分级和病理类型与GATA-3表达相关。因此,GATA-3在乳腺癌的诊断和预后中具有重要作用。
Objective To investigate the transcription factors GATA-3 expression in breast cancer tissue and its clinical value. Methods A total of 382 cases of breast cancer in our hospital from May 1,2013 to November 1,2015 were selected as the research subjects and divided into the breast malignant tumor tissue group（254 cases）,breast benign tumor tissue group（58cases） and breast paracancerous tissue group（70 cases）. The GATA-3 expression levels were comparatively observed in various groups. The relationship between GATA-3 expression with breast cancer morphological classification and between GATA-3 expression with the clinicopathological features of breast cancer were analyzed. Results The GATA-3 expression positive rates in breast malignant tumor tissue was 79.53%（202/254）. The GATA-3 positive rate in the 3-negative type breast cancer cells was lower than that in the glandular lumen type A and B,HER-2 overexpression type,and the differences were statistically significant（P〈0.05）. GATA-3 was expressed in invasive ductal cancer tissue,invasive lobular cancer tissue and neuroendocrine cancer tissue,while not expressed in diffuse large B cell lymphoma and malignant spindle cells tumor tissues. Conclusion The pathological classification and pathological type of breast tumor in breast cancer cells is closely related with GATA-3 expression. Therefore,GATA-3 has an important role in the diagnosis and prognosis of breast cancer.
出处
《现代医药卫生》
2016年第9期1290-1291,1295,共3页
Journal of Modern Medicine & Health
基金
河北省卫生厅医学科学研究重点课题计划项目(20150965)
关键词
乳腺肿瘤
转录因子
DNA结合蛋白质类
乳腺癌组织
Breast neoplasms
Transcription factors
DNA-binding proteins
Breast cancer tissue
