摘要
目的探讨脑梗死患者血浆纤维蛋白原、D-二聚体(D-D)、N-末端脑钠肽前体(NT-pro BNP)水平的变化及其对日常生活活动能力的影响。方法选择发病时间小于72 h的脑梗死患者100例作为脑梗死组,另外,选择同期我院体检中心患者79例作为对照组,测定其血浆纤维蛋白原、D-D、NT-pro BNP的水平。将脑梗死组患者按美国国立卫生研究院卒中量表评分分为NIHSS≤7分组和NIHSS>7分组。结果 (1)脑梗死组较对照组比较三者均高。(2)脑梗死组中三个指标NIHSS≤7分组均低于NIHSS>7分组,且均有统计学意义。(3)多因素线性回归分析显示血浆纤维蛋白原、D-D、NT-pro BNP水平的升高是脑梗死患者恢复期生活活动能力的影响因素。结论血浆纤维蛋白原、D-D、NT-pro BNP水平在脑梗死急性期明显升高,与疾病的严重程度相关,三者均是脑梗死的危险因素,且影响其预后。
Objective： To investigate changes of plasma fibrinogen,D-D and NT-pro BNP levels in patients with acute cerebral infarction and their impact on prognosis. Methods： 100 patients with cerebral infarction cerebral and time of onset 72 h as a cerebral infarction group,and another 79 healthy subjects in the same period were selected as a control group,and plasma fibrinogen,D-D and NT-pro BNP levels in both groups were measured. The group of patients with cerebral infarction were divided into the US National Institutes of Health Stroke Scale（ NIHSS） scores NIHSS≤7 grouping and NIHSS〉 7 grouping. Results：（ 1） The fibrinogen,D-D and NT-pro BNP levels in cerebral infarction group higher than those in the control group.（ 2） In cerebral infarction group： The fibrinogen,D-D and NT-pro BNP levels in NIHSS≤7 groug were lower than those in NIHSS 〉7 group,and were statistically different.（ 3） Multiple linear regression analysis showed that plasma fibrinogen,DD and elevated NT-pro BNP levels were factors in convalescence life ability of patients with cerebral infarction. Conclusion： Plasma fibrinogen,D-D and NT-pro BNP levels are significantly elevated in acute cerebral infarction,which are related to the severity of the disease,and the three are risk factors of cerebral infarction and have the impact on the prognosis.
出处
《泰山医学院学报》
CAS
2016年第3期248-250,共3页
Journal of Taishan Medical College
