血浆同型半胱氨酸水平与脑梗死的关系被引量：13

Study on plasma homocyseine(HCY) levels in patients with cerebral infarction

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摘要目的探讨脑梗死与血浆同型半胱氨酸(H cy)水平的关系。方法测定400例脑梗死患者及200例同期住院既往无临床心脑血管病患者的血液总同型半胱氨酸(H cy),维生素B12和叶酸(FA)。结果血液H cy水平,脑梗死组(17.25±7.11)μm o l/L,对照组(10.48±3.01)μm o l/L,差异有显著意义(P<0.01)高同型半胱氨酸在≤40岁患者中危险因素更明显。血清tH cy水平与V itB12及FA水平呈负相关。结论血清tH cy水平升同增加脑梗死的危险度。 Objective To investigate the relationship between cerebral infarction and plasma level of homocysteine（Hcy）. Methods The serum level Hcy,folate（FA）and vitaminB12（VitB12）of 400 patients with cerebral infarction and 200 patients without history of clinical cardiovascular diseases and cerebrovascular diseases were measured. Results The serum level of Hcy,in the cerebral infarction group（17.25±7, 11μmol/L） was higher than that of control grouop （10.48±3.01μmol/L）. The difference of serum level was significant between cerebral infarction group and control group（P〈0.01 ）. The risk factor in patients of less than 40 years old was especially higher than control guoup. The level of serum Hcy was negative correlction with that of FA and VitB12. Conclusion The high level of serum Hcy is correlated with risk factor for cerebral infarction.

作者王国珍梁海燕王传根

机构地区台州市立医院神经内科

出处《中风与神经疾病杂志》 CAS CSCD 北大核心 2006年第3期338-340,共3页 Journal of Apoplexy and Nervous Diseases

关键词同型半胱氨酸脑梗死叶酸维生素B12 Homocysteine Cerebral infarction Folate VitaminB12

分类号 R743.3 [医药卫生—神经病学与精神病学]

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